POLA2 - DNA polymerase alpha 2, accessory subunit Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23649

About POLA2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,261,962-65,305,985 (from NCBI)

This gene has 8 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in lymph node (RPKM 4.3), appendix (RPKM 2.9) and 25 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in DNA replication, synthesis of RNA primer. Located in cytosol and nucleoplasm. Part of alpha DNA polymerase:primase complex. [provided by Alliance of Genome Resources, Apr 2022]

POLA2 Products (1)

mRNA Protein Name
NM_002689.4 NP_002680.2 DNA polymerase alpha subunit B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32353859 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA replication initiation IDA
IDA: Inferred from direct assay
26975377 GOA
involved in DNA replication, synthesis of primer IDA
IDA: Inferred from direct assay
8026492 GOA
Cellular Component GO Annotation Evidence References Source
part of alpha DNA polymerase:primase complex IDA
IDA: Inferred from direct assay
8026492 GOA
part of alpha DNA polymerase:primase complex IPI
IPI: Inferred from physical interaction
26975377 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLA2 Protein Structure

Pol_alpha_B_N

Pol_alpha_B_N: DNA polymerase alpha subunit B N-terminal (15 - 248)

DNA_pol_E_B

DNA_pol_E_B: DNA polymerase alpha/epsilon subunit B (342 - 549)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 598 a.a.
Protein Preferred Names Protein Names

DNA polymerase alpha subunit B

  • DNA polymerase alpha 70 kDa subunit

POLA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
POLA2 Q14181 FKBP1A Homo sapiens Q0VDC6
Validated Y2H
32814053
Intra
POLA2 Q14181 FKBP1A Homo sapiens Q0VDC6
Y2H Pooling
32814053
Intra
POLA2 Q14181 FKBP1A Homo sapiens Q0VDC6
Y2H Array
32814053
Intra
POLA2 Q14181 SARS1 Homo sapiens P49591
Validated Y2H
32814053
Intra
POLA2 Q14181 SARS1 Homo sapiens P49591
Y2H Pooling
32814053
Intra
POLA2 Q14181 SARS1 Homo sapiens P49591
Y2H Array
32814053
Cross
POLA2 Q14181 P0DTD1-PRO_0000449619 SARS-CoV-2 P0DTD1-PRO_0000449619
Y2H Array
36217030
Intra
POLA2 Q14181 ERN1 Homo sapiens O75460-2
Y2H Array
32814053
Intra
POLA2 Q14181 ERN1 Homo sapiens O75460-2
Y2H Pooling
32814053
Intra
POLA2 Q14181 ERN1 Homo sapiens O75460-2
Validated Y2H
32814053
Intra
POLA2 Q14181 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
POLA2 Q14181 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
POLA2 Q14181 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E71047 DNA Polymerase Alpha, Human / Unkown
HY-RS10817 POLA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus POLA2 MGD MGI:99690
Felis catus POLA2 VGNC VGNC:81958
Macaca mulatta POLA2 VGNC VGNC:101380
Rattus norvegicus POLA2 RGD RGD:621817
Canis familiaris POLA2 VGNC VGNC:44772
Bos taurus POLA2 VGNC VGNC:33111
Others POLA2 NCBI