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Park7 - Parkinson disease (autosomal recessive, early onset) 7 Gene

Also Known as Dj1; DJ-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 57320

Summary

Enables oxygen sensor activity and peroxiredoxin activity. Involved in several processes, including detoxification of inorganic compound; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of protein metabolic process. Acts upstream of or within several processes, including dopamine uptake involved in synaptic transmission; membrane hyperpolarization; and positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway. Located in several cellular components, including cell body; endoplasmic reticulum; and mitochondrion. Is expressed in central nervous system and retina. Used to study Parkinson's disease 7. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase). [provided by Alliance of Genome Resources, Apr 2022]

Park7 Products (1)

mRNA	Protein	Name
NM_020569.3	NP_065594.2	Parkinson disease protein 7 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables oxygen sensor activity	IMP IMP: Inferred from mutant phenotype	17766438	MGI
enables peroxiredoxin activity	IMP IMP: Inferred from mutant phenotype	17766438	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14752510	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	15721235	MGI
involved in cellular response to glyoxal	IMP IMP: Inferred from mutant phenotype	22523093	MGI
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	21068725	MGI
acts upstream of or within cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	16624565	MGI
involved in detection of oxidative stress	IMP IMP: Inferred from mutant phenotype	17766438	MGI
involved in detoxification of copper ion	IMP IMP: Inferred from mutant phenotype	23792957	MGI
involved in detoxification of mercury ion	IMP IMP: Inferred from mutant phenotype	23792957	MGI
acts upstream of or within dopamine uptake involved in synaptic transmission	IMP IMP: Inferred from mutant phenotype	15721235	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	22611253	MGI
involved in glycolate biosynthetic process	IDA IDA: Inferred from direct assay	22523093	MGI
involved in glyoxal metabolic process	IDA IDA: Inferred from direct assay	22523093	MGI
acts upstream of or within hydrogen peroxide metabolic process	IMP IMP: Inferred from mutant phenotype	17766438	MGI
involved in insulin secretion	IMP IMP: Inferred from mutant phenotype	22611253	MGI
acts upstream of or within membrane depolarization	IMP IMP: Inferred from mutant phenotype	16624565	MGI
acts upstream of or within membrane hyperpolarization	IMP IMP: Inferred from mutant phenotype	16624565	MGI
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	20186336	MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	14652021	MGI
involved in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	14652021	MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	24947010	MGI
acts upstream of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	22523093	MGI
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	24899725	MGI
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	24899725	MGI
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	24899725	MGI
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	22611253	MGI
involved in positive regulation of NAD(P)H oxidase activity	IMP IMP: Inferred from mutant phenotype	26021615	MGI
involved in positive regulation of acute inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	26021615	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22492997	MGI
involved in positive regulation of mitochondrial electron transport, NADH to ubiquinone	IMP IMP: Inferred from mutant phenotype	19822128	MGI
involved in positive regulation of oxidative phosphorylation uncoupler activity	IMP IMP: Inferred from mutant phenotype	21068725	MGI
acts upstream of or within positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	22555455	MGI
acts upstream of or within positive regulation of reactive oxygen species biosynthetic process	IDA IDA: Inferred from direct assay	22555455	MGI
acts upstream of positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17015834	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	17015834	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	19276172	MGI
involved in regulation of synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	29386384	MGI
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	29386384	MGI
acts upstream of or within response to hydrogen peroxide	IDA IDA: Inferred from direct assay	15784737	MGI
acts upstream of or within response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	15784737	MGI
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	15784737	MGI
acts upstream of or within synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	15799973	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell body	IDA IDA: Inferred from direct assay	24947010	MGI
located in cytosol	IDA IDA: Inferred from direct assay	15944198	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22555455	MGI
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	15944198	MGI
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	15944198	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	15944198	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	24947010	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22555455	MGI
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	29386384	MGI
is active in synaptic vesicle	IMP IMP: Inferred from mutant phenotype	29386384	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
Parkinson disease protein 7 homolog	RNA-binding protein regulatory subunit maillard deglycase parkinson disease protein 7 homolog parkinsonism-associated deglycase protein DJ-1 protein deglycase DJ-1 protein/nucleic acid deglycase DJ-1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163562	JYQ-164	Inhibitor	99.43%	Unkown
HY-163563	JYQ-173	Inhibitor	99.78%	Unkown
HY-163564	JYQ-194	Degrader	98.05%	Unkown
HY-RS10043	PARK7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17611	Park7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24071	Park7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Park7	NCBI	NCBI:11315