ARHGAP21 - Rho GTPase activating protein 21 Gene

Also Known as ARHGAP10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57584

About ARHGAP21

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:24,583,614-24,723,887 (from NCBI)

This gene has 19 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 26.0), fat (RPKM 12.0) and 25 other tissues.

Summary

ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]

ARHGAP21 Products (10)

mRNA	Protein	Name
NM_001367447.1	NP_001354376.1	rho GTPase-activating protein 21 isoform b
NM_001367448.1	NP_001354377.1	rho GTPase-activating protein 21 isoform a
NM_001367449.1	NP_001354378.1	rho GTPase-activating protein 21 isoform c
NM_001367450.1	NP_001354379.1	rho GTPase-activating protein 21 isoform c
NM_001367451.1	NP_001354380.1	rho GTPase-activating protein 21 isoform b
NM_001367452.1	NP_001354381.1	rho GTPase-activating protein 21 isoform d
NM_001367453.1	NP_001354382.1	rho GTPase-activating protein 21 isoform b
NM_001367454.1	NP_001354383.1	rho GTPase-activating protein 21 isoform a
NM_001367455.1	NP_001354384.1	rho GTPase-activating protein 21 isoform e
NM_020824.4	NP_065875.3	rho GTPase-activating protein 21 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	20525016	GOA
involved in establishment of Golgi localization	IDA IDA: Inferred from direct assay	20525016	GOA
involved in maintenance of Golgi location	IMP IMP: Inferred from mutant phenotype	20525016	GOA
involved in organelle transport along microtubule	IMP IMP: Inferred from mutant phenotype	20525016	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	20525016	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP21 Protein Structure

PDZ

PH

RhoGAP

0
400
800
1200
1600
1958 a.a.

Protein Preferred Names	Protein Names
rho GTPase-activating protein 21	Rho-GTPase activating protein 10

ARHGAP21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	ARHGAP21	Q5T5U3	Arf1	Mus musculus	P84078	X-Ray Diffraction	17347647
Cross	ARHGAP21	Q5T5U3	Arf1	Mus musculus	P84078	Cosedimentation	17347647
Intra	ARHGAP21	Q5T5U3	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	ARHGAP21	Q5T5U3	EEF1D	Homo sapiens	P29692	TAP	20195357
Intra	ARHGAP21	Q5T5U3	SFN	Homo sapiens	P31947	TAP	15778465

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Aarskog-Scott Syndrome	Aarskog Syndrome Faciogenital Dysplasia Faciodigitogenital Syndrome AAS Fgdy X-Linked Aarskog Syndrome Intellectual Developmental Disorder, X-Linked, Syndromic 16 Aarskog Syndrome, X-Linked Intellectual Developmental Disorder, X-Linked Syndromic 16 Greig'S Syndrome Aarskog Scott Syndrome Aarskog Disease Scott Aarskog Syndrome Facio-Digito-Genital Dysplasia Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder Aarskog-Scott Syndrome ) Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00921	ARHGAP21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ARHGAP21	RGD	RGD:1311028
Canis familiaris	ARHGAP21	VGNC	VGNC:38051
Felis catus	ARHGAP21	VGNC	VGNC:59879
Bos taurus	ARHGAP21	VGNC	VGNC:26080
Macaca mulatta	ARHGAP21	VGNC	VGNC:100296
Mus musculus	ARHGAP21	MGD	MGI:1918685
Others	ARHGAP21	NCBI