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Cat. No.: HY-N21624

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Pleioside A

Pleioside A is a flavonoid glycoside with immunomodulatory activity that is found in the leaves of Pleioblastus amarus. Pleioside A exerts differential regulatory effects on adaptive immune lymphocyte proliferation by inhibiting mouse T cell proliferation and promoting B lymphocyte proliferation. Pleioside A can be used for research on adaptive immunity and immunomodulation.

For research use only. We do not sell to patients.

CAS No.: 199925-44-5
Formula: C₂₄H₂₆O₁₂
Molecular Weight:506.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pleioside A Chemical Structure

CAS No.: 199925-44-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Pleioside A (compound 1) (40 μM; 48 h) inhibits ConA-induced mouse T cell proliferation^[1].
Pleioside A (400 nM-40 μM; 48 h) significantly stimulates LPS (HY-D1056)-induced proliferation of mouse B lymphocytes, with a strong stimulatory effect observed at 40 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

mouse spleen cells
Concentration:

400 nM, 4 μM, 40 μM
Incubation Time:

48 h
Result:

Inhibited ConA-induced T cell proliferation in a concentration-dependent manner.
At 400 nM, ³H-TdR incorporation was 100.68 × 10³ cpm.
At 4 μM, ³H-TdR incorporation decreased to 97.13 × 10³ cpm.
At 40 μM, ³H-TdR incorporation decreased further to 90.18 × 10³ cpm, representing a marked inhibition compared to the ConA positive control value of 107.24 × 10³ cpm.\nStimulated LPS-induced B cell proliferation in a concentration-dependent manner.
At 400 nM, ³H-TdR incorporation was 30.97 × 10³ cpm.
At 4 μM, ³H-TdR incorporation increased to 34.35 × 10³ cpm.
At 40 μM, ³H-TdR incorporation rose further to 40.87 × 10³ cpm, representing a marked stimulation compared to the LPS positive control value of 28.91 × 10³ cpm.

Chemical Information

CAS No. 199925-44-5
Molecular Weight 506.46
Formula C₂₄H₂₆O₁₂
SMILES

O=C1C2=C(O)C=C(OC)C=C2OC(C3=CC(OC)=C(C(OC)=C3)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1
Structure Classification
- Flavonoids
- Flavones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang HB, et al. Flavone glucosides with immunomodulatory activity from the leaves of Pleioblastus amarus. Phytochemistry. 2004 Apr;65(7):969-74.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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