Val-Cit-PAB-DEA-Dxd TFA

Cat. No.: HY-158137A Purity: 99.11%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Val-Cit-PAB-DEA-Dxd (Compound 81) TFA is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule Dxd (HY-13631D). Val-Cit-PAB-DEA-Dxd can be used for ADC synthesis.

For research use only. We do not sell to patients.

Val-Cit-PAB-DEA-Dxd TFA Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Val-Cit-PAB-DEA-Dxd TFA:

Val-Cit-PAB-DEA-Dxd Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Val-Cit-PAB-DEA-Dxd (Compound 81) TFA is a Drug-Linker Conjugates for ADC, which is composed of a linker and a toxic molecule Dxd (HY-13631D). Val-Cit-PAB-DEA-Dxd can be used for ADC synthesis^[1].

Molecular Weight

1127.10

Formula

C₅₂H₆₂F₄N₁₀O₁₄

Appearance

Solid

Color

Light yellow to yellow

SMILES

CN(C(OCC1=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)N)=O)=O)C=C1)=O)CCN(C)C(OCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (88.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8872 mL	4.4362 mL	8.8723 mL
5 mM	0.1774 mL	0.8872 mL	1.7745 mL
10 mM	0.0887 mL	0.4436 mL	0.8872 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.11%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (261 KB) HNMR (481 KB) RP-HPLC (229 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Dechun Wu, et al. Pegylated antibody hydroxyl-bearing drug conjugate. Patent WO2023151679A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8872 mL	4.4362 mL	8.8723 mL	22.1808 mL
	5 mM	0.1774 mL	0.8872 mL	1.7745 mL	4.4362 mL
	10 mM	0.0887 mL	0.4436 mL	0.8872 mL	2.2181 mL
	15 mM	0.0591 mL	0.2957 mL	0.5915 mL	1.4787 mL
	20 mM	0.0444 mL	0.2218 mL	0.4436 mL	1.1090 mL
	25 mM	0.0355 mL	0.1774 mL	0.3549 mL	0.8872 mL
	30 mM	0.0296 mL	0.1479 mL	0.2957 mL	0.7394 mL
	40 mM	0.0222 mL	0.1109 mL	0.2218 mL	0.5545 mL
	50 mM	0.0177 mL	0.0887 mL	0.1774 mL	0.4436 mL
	60 mM	0.0148 mL	0.0739 mL	0.1479 mL	0.3697 mL
	80 mM	0.0111 mL	0.0555 mL	0.1109 mL	0.2773 mL