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Cat. No.: HY-118555

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Vascular disrupting agent 1

Vascular disrupting agent 1 is an active compound.

For research use only. We do not sell to patients.

CAS No.: 875468-82-9
Formula: C₁₇H₁₁N₃OS
Molecular Weight:305.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Vascular disrupting agent 1 Chemical Structure

CAS No.: 875468-82-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Vascular disrupting agent 1 is an active compound.

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7.7 μM Compound: TBZ-07	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation rate after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation rate after 72 hrs by MTT assay	[PMID: 25936258]
HCT-116	IC₅₀	2.46 μM Compound: TBZ-07	Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation rate after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation rate after 72 hrs by MTT assay	[PMID: 25936258]
HepG2	IC₅₀	7.58 μM Compound: TBZ-07	Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation rate after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation rate after 72 hrs by MTT assay	[PMID: 25936258]
HUVEC	IC₅₀	9.22 μM Compound: TBZ-07	Cytotoxicity against HUVEC assessed as inhibition of cell proliferation rate after 72 hrs by MTT assay Cytotoxicity against HUVEC assessed as inhibition of cell proliferation rate after 72 hrs by MTT assay	[PMID: 25936258]

Chemical Information

CAS No. 875468-82-9
Molecular Weight 305.35
Formula C₁₇H₁₁N₃OS
SMILES

O=C(C1=CC=C2C(N=C(N2)C3=CSC=N3)=C1)C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Synthesis and biological evaluation of thiabendazole derivatives as anti-angiogenesis and vascular disrupting agents

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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