VU6080824 hydrochloride

Cat. No.: HY-178058A Purity: 98.88%: Data Sheet
COA

SDS
Handling Instructions
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VU6080824 (hydrochloride), a derivative of ML-133 (HY-100230), is an inward-rectifier potassium channel (K_ir2.1) inhibitor with an IC₅₀ of 0.35  μM. VU6080824 (hydrochloride) has superior thallium flux and manual patch clamp (MPC) functional potency.

For research use only. We do not sell to patients.

VU6080824 hydrochloride Chemical Structure

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of VU6080824 hydrochloride:

VU6080824 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

369.88

Formula

C₂₂H₂₄ClNO₂

Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(C=C1)CNCC2=CC=C(C3=CC=CC(OC)=C3)C=C2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (54.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7036 mL	13.5179 mL	27.0358 mL
5 mM	0.5407 mL	2.7036 mL	5.4072 mL
10 mM	0.2704 mL	1.3518 mL	2.7036 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.88%

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Data Sheet (266 KB) SDS (252 KB)

COA (244 KB) HNMR (270 KB) LCMS (341 KB)

Handling Instructions (2659 KB)

References

[1]. Duncan RA, et al. Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel Kir2.1: Discovery of VU6080824. ACS Med Chem Lett. 2025 Aug 29;16(9):1762-1771. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7036 mL	13.5179 mL	27.0358 mL	67.5895 mL
	5 mM	0.5407 mL	2.7036 mL	5.4072 mL	13.5179 mL
	10 mM	0.2704 mL	1.3518 mL	2.7036 mL	6.7589 mL
	15 mM	0.1802 mL	0.9012 mL	1.8024 mL	4.5060 mL
	20 mM	0.1352 mL	0.6759 mL	1.3518 mL	3.3795 mL
	25 mM	0.1081 mL	0.5407 mL	1.0814 mL	2.7036 mL
	30 mM	0.0901 mL	0.4506 mL	0.9012 mL	2.2530 mL
	40 mM	0.0676 mL	0.3379 mL	0.6759 mL	1.6897 mL
	50 mM	0.0541 mL	0.2704 mL	0.5407 mL	1.3518 mL