VULM 1457 (Standard)
VULM 1457 (Standard) is the analytical standard of VULM 1457 (HY-107571). This product is intended for research and analytical applications. VULM 1457 is a potent inhibitor of cholesterol acyltransferase (acyl-CoA). VULM1457 significantly reduces production and secretion of adrenomedullin (AM) and down-regulates AM receptors on human hepatoblastic cells. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM 1457 has the potential for the research of diabetes mellitus and hypercholesterolaemia.
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- CAS No.: 228544-65-8
- 화학식: C25H27N3O3S
- 분자량:449.57
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
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PD 128042 (Standard)ACAT/LPAT Inhibitor -
HY-107396R
YM-750 (Standard)Reference Standard -
HY-107569
GarcinolAChE Inhibitor
Biological Activity
제품 설명
IC50 & Target
acyl-CoA[1]
Chemical Information
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CAS No. 228544-65-8
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분자량 449.57
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화학식 C25H27N3O3S
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SMILES
O=C(NC1=CC=C(SC2=CC=C([N+]([O-])=O)C=C2)C=C1)NC3=C(C=CC=C3C(C)C)C(C)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. J Drímal, et al. The ACAT inhibitor VULM1457 significantly reduced production and secretion of adrenomedullin (AM) and down-regulated AM receptors on human hepatoblastic cells. Gen Physiol Biophys. 2005 Dec;24(4):397-409. [Content Brief]
[2]. Adameová A, et al. The myocardial infarct size-limiting and antiarrhythmic effects of acyl-CoA:cholesterol acyltransferase inhibitor VULM 1457 protect the hearts of diabetic-hypercholesterolaemic rats against ischaemia/reperfusion injury both in vitro and in vivo. Eur J Pharmacol. 2007;576(1-3):114-121. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VULM 1457 (Standard) Related Classifications
HY-107571R Related Classifications
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Keywords
- VULM 1457 (Standard)
- 228544-65-8
- Reference Standards
- Acyltransferase
- Diacylglycerol acyltransferase
- Diglyceride acyltransferase
- acyl-CoA:cholesterol acyltransferase
- mono- acylglycerol acyltransferase
- cholesterol acyltransferase
- acyl-CoA
- hypolipidaemic
- diabetes mellitus
- hypercholesterolaemia
- myocardial
- ischaemia-reperfusion
- Inhibitor
- inhibitor
- inhibit