WAY 629 hydrochloride

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WAY 629 hydrochloride is a potent and selective 5-HT_2C agonist with EC₅₀s of 426, 260000 nM for 5-HT_2C and 5-HT_2A, respectively. WAY 629 hydrochloride decreases feeding behavior.

For research use only. We do not sell to patients.

WAY 629 hydrochloride Chemical Structure

CAS No. : 57756-44-2

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Biological Activity
Purity & Documentation
References
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Description

WAY 629 hydrochloride is a potent and selective 5-HT_2C agonist with EC₅₀s of 426, 260000 nM for 5-HT_2C and 5-HT_2A, respectively. WAY 629 hydrochloride decreases feeding behavior^[1]^[2].

IC₅₀ & Target^[1]

5-HT_2C Receptor

426 nM (EC₅₀)

5-HT_2A Receptor

260000 nM (EC₅₀)

In Vivo

WAY 629 hydrochloride (30 mg/kg; i.p.) decreases feeding behavior in rats^[1].
WAY 629 hydrochloride (21 mg/kg; i.p.) decreases the expression of NPY mRNA in mice brains^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	WT mice^[2]
Dosage:	21 mg/kg
Administration:	I.p.
Result:	Decreased the expression of NPY mRNA.

Molecular Weight

262.78

Formula

C₁₅H₁₉ClN₂

CAS No.

57756-44-2

SMILES

[H]Cl.N1(CCNC2)C3=C(C4=CC=CC2=C41)CCCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sabb AL, et al. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7. [Content Brief]

[2]. Aoki M, et al. Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair. Eur J Neurosci. 2016 May;43(9):1219-28. [Content Brief]