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WAY 629

WAY 629 is a potent and selective 5-HT_2C agonist with EC₅₀s of 426, 260000 nM for 5-HT_2C and 5-HT_2A, respectively. WAY 629 decreases feeding behavior.

For research use only. We do not sell to patients.

CAS No.: 57756-45-3
Formula: C₁₅H₁₈N₂
Molecular Weight:226.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

WAY 629 Chemical Structure

CAS No.: 57756-45-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

WAY 629 is a potent and selective 5-HT_2C agonist with EC₅₀s of 426, 260000 nM for 5-HT_2C and 5-HT_2A, respectively. WAY 629 decreases feeding behavior^[1]^[2].

IC₅₀ & Target^[1]

5-HT_2A Receptor

5-HT_2C Receptor

426 nM (EC₅₀)

5-HT_2A Receptor

260000 nM (EC₅₀)

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	261 nM Compound: 6, WAY-629	Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay Agonist activity at human 5HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	[PMID: 19284718]

In Vivo

WAY 629 (30 mg/kg; i.p.) decreases feeding behavior in rats^[1].
WAY 629 (21 mg/kg; i.p.) decreases the expression of NPY mRNA in mice brains^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

WT mice^[2]
Dosage:

21 mg/kg
Administration:

I.p.
Result:

Decreased the expression of NPY mRNA.

Chemical Information

CAS No. 57756-45-3
Molecular Weight 226.32
Formula C₁₅H₁₈N₂
SMILES

N1(CCNC2)C3=C(C4=CC=CC2=C41)CCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sabb AL, et al. Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg Med Chem Lett. 2004 May 17;14(10):2603-7. [Content Brief]

[2]. Aoki M, et al. Involvement of serotonin 2C receptor RNA editing in accumbal neuropeptide Y expression and behavioural despair. Eur J Neurosci. 2016 May;43(9):1219-28. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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