Xanthine oxidoreductase-IN-3

Name: Xanthine oxidoreductase-IN-3
Brand: MedChemExpress
SKU: HY-151973
Rating: 4.5 (0 reviews)

Cat. No.: HY-151973: Fiche technique Instruction de manipulation
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Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC₅₀ of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia.

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Xanthine oxidoreductase-IN-3 Chemical Structure

CAS No. : 651769-78-7

Size	Stock	Quantité
1 mg	Obtenir un devis 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Obtenir un devis 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Obtenir un devis 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
25 mg	Obtenir un devis 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Obtenir un devis 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 mg	Obtenir un devis
200 mg	Obtenir un devis

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Activité biologique
Pureté et documentation
Références
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Description

IC₅₀ & Target

IC50: 26.3 nM (xanthine oxidoreductase)^[1]

In Vivo

Xanthine oxidoreductase-IN-3 (compound IIIa) (5 mg/kg; p.o.) shows a uric acid-lowering effect from 3 h after administration in mice with acute hyperuricemia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine^[1]
Dosage:	5 mg/kg
Administration:	Suspended in 0.5% CMC-Na solution for intragastric administration
Result:	Showed a uric acid-lowering effect from 3 h after administration.

Masse moléculaire

299.72

Formule

C₁₄H₁₀ClN₅O

CAS No.

651769-78-7

SMILES

O=C(C1=CC=C(C=C1)C2=NN=NN2)NC3=CC=C(C=C3)Cl

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Peng W, et, al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947. [Content Brief]