Xanthine oxidoreductase-IN-3
Xanthine oxidoreductase-IN-3 is an orally active xanthine oxidoreductase (XOR) inhibitor, with an IC50 of 26.3 nM. Xanthine oxidoreductase-IN-3 can be used for the research of acute hyperuricemia.
For research use only. We do not sell to patients.
- CAS No.: 651769-78-7
- Formula: C14H10ClN5O
- Molecular Weight:299.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 26.3 nM (xanthine oxidoreductase)[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (18-22 g) were induced acute hyperuricemia by injection of potassium oxonate and hypoxanthine[1]
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Dosage:5 mg/kg
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Administration:Suspended in 0.5% CMC-Na solution for intragastric administration
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Result:Showed a uric acid-lowering effect from 3 h after administration.
Chemical Information
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CAS No. 651769-78-7
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Molecular Weight 299.72
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Formula C14H10ClN5O
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SMILES
O=C(C1=CC=C(C=C1)C2=NN=NN2)NC3=CC=C(C=C3)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Xanthine oxidoreductase-IN-3 Related Classifications
HY-151973 Related Classifications
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