2. Autophagy
  3. p62 Atg8/LC3 Autophagy
  4. XIE62-1004-A

XIE62-1004-A is an inducer of p62-LC3 interaction. XIE62-1004-A can bind to the ZZ-domain of p62, inducing p62 oligomerization and activating p62-dependent autophagy.

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XIE62-1004-A

XIE62-1004-A Chemische Struktur

CAS. Nr. : 2421146-32-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Beschreibung

XIE62-1004-A is an inducer of p62-LC3 interaction. XIE62-1004-A can bind to the ZZ-domain of p62, inducing p62 oligomerization and activating p62-dependent autophagy[1].

IC50 & Target

p62[1]
Molekulargewicht

399.91

Formel

C23H26ClNO3
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

OCCNCC1=CC=C(C(OCC2=CC=CC=C2)=C1)OCC3=CC=CC=C3.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (312.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 5 mg/mL (12.50 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5006 mL 12.5028 mL 25.0056 mL
5 mM 0.5001 mL 2.5006 mL 5.0011 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.89%

SDS (393 KB)

COA (247 KB) HNMR (262 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.5006 mL 12.5028 mL 25.0056 mL 62.5141 mL
5 mM 0.5001 mL 2.5006 mL 5.0011 mL 12.5028 mL
10 mM 0.2501 mL 1.2503 mL 2.5006 mL 6.2514 mL
DMSO 15 mM 0.1667 mL 0.8335 mL 1.6670 mL 4.1676 mL
20 mM 0.1250 mL 0.6251 mL 1.2503 mL 3.1257 mL
25 mM 0.1000 mL 0.5001 mL 1.0002 mL 2.5006 mL
30 mM 0.0834 mL 0.4168 mL 0.8335 mL 2.0838 mL
40 mM 0.0625 mL 0.3126 mL 0.6251 mL 1.5629 mL
50 mM 0.0500 mL 0.2501 mL 0.5001 mL 1.2503 mL
60 mM 0.0417 mL 0.2084 mL 0.4168 mL 1.0419 mL
80 mM 0.0313 mL 0.1563 mL 0.3126 mL 0.7814 mL
100 mM 0.0250 mL 0.1250 mL 0.2501 mL 0.6251 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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XIE62-1004-A Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XIE62-1004-A2421146-32-7p62Atg8/LC3AutophagySequestosome-1SQSTM1Autophagy-related 8| ZZ-domainautophagyLC3Inhibitorinhibitorinhibit

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