YopE(69-77)
YopE (69-77) is an H-2Kb-restricted immunodominant protective bacterial epitope that binds with high affinity to mouse H-2Kb and human HLA-A26:01 class I MHC alleles. YopE is a virulence factor derived from Yersinia pseudotuberculosis, Yersinia pestis, and serogroups O9 and O3 of Yersinia enterocolitica. YopE (69-77) can be used in studies related to Yersinia pseudotuberculosis infection.
For research use only. We do not sell to patients.
- CAS No.: 1357447-10-9
- Formula: C47H79N13O12S
- Molecular Weight:1050.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
YopE(69-77) displays strong predicted binding affinity for mouse H-2Kb (IC50 = 20 nM) and human HLA-A26:01 (IC50 = 12 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1357447-10-9
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Molecular Weight 1050.28
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Formula C47H79N13O12S
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Sequence
Ser-Val-Ile-Gly-Phe-Ile-Gln-Arg-Met
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Sequence Shortening
SVIGFIQRM
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YopE(69-77) Related Classifications
HY-P12181 Related Classifications
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