α-Glucosidase-IN-16
α-Glucosidase-IN-16 is a potent and orally active α-glucosidase inhibitor with an IC50 value of 3.28 μM. α-Glucosidase-IN-16 can reduce the level of blood glucose in Streptozotocin (HY-13753)-induced diabetic rats. Antidiabetic activity.
For research use only. We do not sell to patients.
- CAS No.: 1606142-34-0
- Formula: C22H18FNS
- Molecular Weight:347.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 3.28 μM (α-Glucosidase)[1]
α-Glucosidase-IN-16 (2000 mg/kg; PO; single dosage) exhibits no toxic effects in mice[1].
α-Glucosidase-IN-16 (10 and 20 mg/kg; PO; single dosage) significantly reduces serum glucose level after glucose administration in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (170-200 g, 8-10 weeks; induced diabetes by intraperitoneal injection of Streptozotocin (HY-13753))[1]
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Dosage:10 and 20 mg/kg
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Administration:PO; once daily for 28 days
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Result:Caused a significant reduction in the level of blood glucose compared to diabetic control.
Lowered the total cholesterol level.
Effect of α-Glucosidase-IN-16 on blood glucose (mg/dL) in Streptozotocin-induced diabetes[1].
dose (mg/kg) day 1 day 7 day 14 day 21 day 28 10 370.81 ± 4.79 289.89 ± 4.33 200.33 ± 4.57 149.30 ± 4.56 132.98 ± 4.33 20 375.31 ± 5.01 230.71 ± 4.88 163.68 ± 4.37 120.72 ± 4.11 108.42 ± 3.98
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Animal Model:Balb/C mice[1]
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Dosage:2000 mg/kg
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Administration:PO; single dosage (acute toxicity study)
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Result:Exhibited no toxic effects (via observing signs of diarrhea, convulsions, lethargy, sleeping, salivation, and tremor).
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Animal Model:Wistar rats (oral administration with 3 g/kg glucose)[1]
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Dosage:10 and 20 mg/kg
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Administration:PO; single dosage (oral glucose tolerance test)
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Result:Significantly reduced serum glucose level (110-113 mg/dL) compared to the control group (128 mg/dL) after 2 hours of glucose administration.
Chemical Information
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CAS No. 1606142-34-0
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Molecular Weight 347.45
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Formula C22H18FNS
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SMILES
CC1=CC=C(C2=NC3=CC=CC=C3SC(C4=CC=C(F)C=C4)C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Glucosidase-IN-16 Related Classifications
HY-151138 Related Classifications
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