α-Glucosidase-IN-16
α-Glucosidase-IN-16 is a potent and orally active α-glucosidase inhibitor with an IC50 value of 3.28 μM. α-Glucosidase-IN-16 can reduce the level of blood glucose in Streptozotocin (HY-13753)-induced diabetic rats. Antidiabetic activity.
For research use only. We do not sell to patients.
- CAS No.: 1606142-34-0
- Formula: C22H18FNS
- Molecular Weight:347.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 3.28 μM (α-Glucosidase)[1]
In Vivo
α-Glucosidase-IN-16 (2000 mg/kg; PO; single dosage) exhibits no toxic effects in mice[1].
α-Glucosidase-IN-16 (10 and 20 mg/kg; PO; single dosage) significantly reduces serum glucose level after glucose administration in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (170-200 g, 8-10 weeks; induced diabetes by intraperitoneal injection of Streptozotocin (HY-13753))[1]
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Dosage:10 and 20 mg/kg
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Administration:PO; once daily for 28 days
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Result:Caused a significant reduction in the level of blood glucose compared to diabetic control.
Lowered the total cholesterol level.
Effect of α-Glucosidase-IN-16 on blood glucose (mg/dL) in Streptozotocin-induced diabetes[1].
dose (mg/kg) day 1 day 7 day 14 day 21 day 28 10 370.81 ± 4.79 289.89 ± 4.33 200.33 ± 4.57 149.30 ± 4.56 132.98 ± 4.33 20 375.31 ± 5.01 230.71 ± 4.88 163.68 ± 4.37 120.72 ± 4.11 108.42 ± 3.98
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Animal Model:Balb/C mice[1]
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Dosage:2000 mg/kg
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Administration:PO; single dosage (acute toxicity study)
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Result:Exhibited no toxic effects (via observing signs of diarrhea, convulsions, lethargy, sleeping, salivation, and tremor).
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Animal Model:Wistar rats (oral administration with 3 g/kg glucose)[1]
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Dosage:10 and 20 mg/kg
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Administration:PO; single dosage (oral glucose tolerance test)
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Result:Significantly reduced serum glucose level (110-113 mg/dL) compared to the control group (128 mg/dL) after 2 hours of glucose administration.
Chemical Information
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CAS No. 1606142-34-0
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Molecular Weight 347.45
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Formula C22H18FNS
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SMILES
CC1=CC=C(C2=NC3=CC=CC=C3SC(C4=CC=C(F)C=C4)C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Glucosidase-IN-16 Related Classifications
HY-151138 Related Classifications
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