11β-HSD1-IN-12
11β-HSD1-IN-12 is a 11β-HSD1 inhibitor (Example 21 in reference patent). 11β-HSD1 regenerates active glucocorticoids from inactive forms and is important in regulating intracellular glucocorticoid concentration. 11β-HSD1-IN-12 can be used in the research of obesity and metabolic syndrome.
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- CAS. Nr.: 872506-67-7
- Formel: C19H27ClN2O3S
- Molecular Weight:398.95
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.8 nM
Compound: 1
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Inhibition of human 11-beta HSD1 transfected in HEK293 cell microsomes assessed as decrease in [3H]cortisol generation using [3H]cortisone as substrate measured after 60 mins by scintillation proximity assay
Inhibition of human 11-beta HSD1 transfected in HEK293 cell microsomes assessed as decrease in [3H]cortisol generation using [3H]cortisone as substrate measured after 60 mins by scintillation proximity assay
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[PMID: 23353742] |
Chemical Information
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CAS. Nr. 872506-67-7
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Molecular Weight 398.95
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Formel C19H27ClN2O3S
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SMILES
O=C([C@@H]1CN(S(=O)(C2=CC=CC(Cl)=C2C)=O)CCC1)NC3CCCCC3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (125.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
Verweise
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5066 mL | 12.5329 mL | 25.0658 mL | 62.6645 mL |
| 5 mM | 0.5013 mL | 2.5066 mL | 5.0132 mL | 12.5329 mL | |
| 10 mM | 0.2507 mL | 1.2533 mL | 2.5066 mL | 6.2664 mL | |
| 15 mM | 0.1671 mL | 0.8355 mL | 1.6711 mL | 4.1776 mL | |
| 20 mM | 0.1253 mL | 0.6266 mL | 1.2533 mL | 3.1332 mL | |
| 25 mM | 0.1003 mL | 0.5013 mL | 1.0026 mL | 2.5066 mL | |
| 30 mM | 0.0836 mL | 0.4178 mL | 0.8355 mL | 2.0888 mL | |
| 40 mM | 0.0627 mL | 0.3133 mL | 0.6266 mL | 1.5666 mL | |
| 50 mM | 0.0501 mL | 0.2507 mL | 0.5013 mL | 1.2533 mL | |
| 60 mM | 0.0418 mL | 0.2089 mL | 0.4178 mL | 1.0444 mL | |
| 80 mM | 0.0313 mL | 0.1567 mL | 0.3133 mL | 0.7833 mL | |
| 100 mM | 0.0251 mL | 0.1253 mL | 0.2507 mL | 0.6266 mL |
11β-HSD1-IN-12 Related Classifications
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