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Cat. No.: HY-N10857

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12-Hydroxymyricanone

12-Hydroxymyricanone is a nature product that could be isolated from the roots of Myrica nana. 12-Hydroxymyricanone inhibits the release of nitric oxide with an IC₅₀ value of 30.19 μM.

For research use only. We do not sell to patients.

CAS No.: 191999-68-5
Formula: C₂₁H₂₄O₆
Molecular Weight:372.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

12-Hydroxymyricanone Chemical Structure

CAS No.: 191999-68-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

12-Hydroxymyricanone is a nature product that could be isolated from the roots of Myrica nana. 12-Hydroxymyricanone inhibits the release of nitric oxide with an IC₅₀ value of 30.19 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Macrophage	IC₅₀	30.19 μM Compound: 8	Inhibition of LPS-stimulated nitric oxide production in BALB/c mouse macrophages after 20 hrs by Griess assay relative to control Inhibition of LPS-stimulated nitric oxide production in BALB/c mouse macrophages after 20 hrs by Griess assay relative to control	[PMID: 18723353]

In Vitro

12-Hydroxymyricanone (compound 8; 0-100 μM) inhibits nitric oxide release in Lipopolysaccharides (HY-D1056)-activated peritoneal macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 191999-68-5
Molecular Weight 372.41
Formula C₂₁H₂₄O₆
SMILES

COC1=C2C3=C(O)C=CC(CC(C(CCCCC(C(O)=C1OC)=C2)=O)O)=C3
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang J, et, al. Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release. Bioorg Med Chem. 2008 Sep 15;16(18):8510-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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