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Cat. No.: HY-N20643

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(1R,4aS,5R,6R,8aS)-14-Deoxy-12-hydroxyandrographolide

(1R,4aS,5R,6R,8aS)-14-Deoxy-12-hydroxyandrographolide is an ent-kaurane-type diterpenoid. (1R,4aS,5R,6R,8aS)-14-Deoxy-12-hydroxyandrographolide induces leukemia cell differentiation by enhancing phagocytosis and inhibits leukemia cell growth. (1R,4aS,5R,6R,8aS)-14-Deoxy-12-hydroxyandrographolide can be used in the research of murine myeloid leukemia.

For research use only. We do not sell to patients.

CAS No.: 160495-64-7
Formula: C₂₀H₃₀O₅
Molecular Weight:350.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(1R,4aS,5R,6R,8aS)-14-Deoxy-12-hydroxyandrographolide Chemical Structure

CAS No.: 160495-64-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	78 μM Compound: 22	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 25913115]
MDA-MB-231	IC₅₀	27.6 μM Compound: 22	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 25913115]
NTUB1	IC₅₀	14.93 μM Compound: 22	Cytotoxicity against human NTUB1 cells after 48 hrs by MTT assay Cytotoxicity against human NTUB1 cells after 48 hrs by MTT assay	[PMID: 25913115]

In Vitro

(1R,4aS,5R,6R,8aS)-14-Deoxy-12-hydroxyandrographolide (Compound 9) at 5-50 μM for 48 h induces differentiation of mouse myeloid leukemia (M1) cells and exerts concentration-dependent growth inhibitory effects on M1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 160495-64-7
Molecular Weight 350.45
Formula C₂₀H₃₀O₅
SMILES

C[C@]12[C@@](CCC([C@H]2CC(C3=CCOC3=O)O)=C)([H])[C@@](C)([C@@H](CC1)O)CO
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Plants
- Acanthaceae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matsuda T, et al. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chemical & pharmaceutical bulletin. 1994 Jun;42(6):1216-25. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(1R,4aS,5R,6R,8aS)-14-Deoxy-12-hydroxyandrographolide

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(1R,4aS,5R,6R,8aS)-14-Deoxy-12-hydroxyandrographolide

Biological Activity

Description

Cellular Effect

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(1R,4aS,5R,6R,8aS)-14-Deoxy-12-hydroxyandrographolide Related Classifications

HY-N20643 Related Classifications

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