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Cat. No.: HY-131543

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22-Hydroxy mifepristone

Name: 22-Hydroxy mifepristone
Brand: MedChemExpress
SKU: HY-131543
Price: 285.00 USD
Availability: PreOrder

(Synonyms: RU 42698)

22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcoholic metabolite with antiprogestational and antiglucocorticoidal activities, which contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. The relative binding affinity of 22-Hydroxy Mifepristone to the human glucocorticoid receptor is 48%.

For research use only. We do not sell to patients.

CAS No.: 105012-15-5
Formula: C₃₁H₃₉NO₃
Molecular Weight:473.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

22-Hydroxy mifepristone Chemical Structure

CAS No.: 105012-15-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-W740216
N-Demethyl Mifepristone

Glucocorticoid Receptor Antagonist

Biological Activity

Description

All Endogenous Metabolite Isoforms :

Chemical Information

CAS No. 105012-15-5
Molecular Weight 473.65
Formula C₃₁H₃₉NO₃
SMILES

O=C1C=C2C(CC1)=C3[C@@H](C4=CC=C(N(C)C)C=C4)C[C@@]5(C)[C@@]([C@]3(C)CC2)(C)CC[C@]5(C#CCO)O
Synonyms

RU 42698
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Signal Pathway Related

Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lähteenmäki P, et al. Pharmacokinetics and metabolism of RU 486. J Steroid Biochem. 1987;27(4-6):859-63. [Content Brief]

[2]. Heikinheimo O, et al. Plasma concentrations and receptor binding of RU 486 and its metabolites in humans. J Steroid Biochem. 1987 Feb;26(2):279-84. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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