4-Aminohippuric acid-d4
4-Aminohippuric acid-d4 (p-Aminohippuric acid-d4) is the deuterium labeled 4-Aminohippuric acid (HY-B1306). 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu2+, Fe3+, Hg2+) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD).
For research use only. We do not sell to patients.
- CAS No.: 1219805-41-0
- Formula: C9H6D4N2O3
- Molecular Weight:198.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1219805-41-0
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Unlabeled Cas 61-78-9
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Appearance Solid
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Molecular Weight 198.21
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Formula C9H6D4N2O3
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Color Off-white to light yellow
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SMILES
OC(CNC(C1=C([2H])C([2H])=C(C([2H])=C1[2H])N)=O)=O
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Synonyms
p-Aminohippuric acid-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMF : ≥ 33 mg/mL (166.49 mM)
DMSO : ≥ 20 mg/mL (100.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Rastogi L, et al. Intrinsic peroxidase-like activity of 4-amino hippuric acid reduced/stabilized gold nanoparticles and its application in the selective determination of mercury and iron in ground water. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Mar 5;228:117805. [Content Brief]
[4]. Wang LJ, et al. Novel plasma metabolite markers of attention-deficit/hyperactivity disorder identified using high-performance chemical isotope labelling-based liquid chromatography-mass spectrometry. World J Biol Psychiatry. 2021 Feb;22(2):139-148. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / DMF | 1 mM | 5.0452 mL | 25.2258 mL | 50.4515 mL | 126.1288 mL |
| 5 mM | 1.0090 mL | 5.0452 mL | 10.0903 mL | 25.2258 mL | |
| 10 mM | 0.5045 mL | 2.5226 mL | 5.0452 mL | 12.6129 mL | |
| 15 mM | 0.3363 mL | 1.6817 mL | 3.3634 mL | 8.4086 mL | |
| 20 mM | 0.2523 mL | 1.2613 mL | 2.5226 mL | 6.3064 mL | |
| 25 mM | 0.2018 mL | 1.0090 mL | 2.0181 mL | 5.0452 mL | |
| 30 mM | 0.1682 mL | 0.8409 mL | 1.6817 mL | 4.2043 mL | |
| 40 mM | 0.1261 mL | 0.6306 mL | 1.2613 mL | 3.1532 mL | |
| 50 mM | 0.1009 mL | 0.5045 mL | 1.0090 mL | 2.5226 mL | |
| 60 mM | 0.0841 mL | 0.4204 mL | 0.8409 mL | 2.1021 mL | |
| 80 mM | 0.0631 mL | 0.3153 mL | 0.6306 mL | 1.5766 mL | |
| 100 mM | 0.0505 mL | 0.2523 mL | 0.5045 mL | 1.2613 mL |
4-Aminohippuric acid-d4 Related Classifications
HY-B1306S Related Classifications
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