4-Aminosalicylic acid hemicalcium
Based on 1 publication(s) in Google Scholar
4-Aminosalicylic acid hemicalcium is an inhibitor for dihydrofolate reductase (DHFR) and an antituberculous agent. 4-Aminosalicylic acid hemicalcium exhibits anti-inflammatory activity and can be used in research of inflammatory bowel disease (IBD). 4-Aminosalicylic acid hemicalcium is orally active.
For research use only. We do not sell to patients.
- CAS No.: 133-15-3
- Formula: C7H7NO3.1/2Ca
- Molecular Weight:173.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) 4-Aminosalicylic acid hemicalcium
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Biological Activity
4-Aminosalicylic acid hemicalcium is incorporated into the folate pathway via dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate the hydroxydihydrofolate antimetabolite, which in turn inhibits DHFR enzyme activity[1].
4-Aminosalicylic acid hemicalcium inhibits M. tuberculosis H37Rv growth with MIC value of 0.4 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 133-15-3
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Molecular Weight 173.18
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Formula C7H7NO3.1/2Ca
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SMILES
O=C(O)C1=CC=C(N)C=C1O.[0.5 Ca]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227
Purity & Documentation
References
[1]. Zheng J, et al. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013 Aug 9;288(32):23447-56. [Content Brief]
[2]. Abdu-Allah HHM, et al. Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids. Bioorg Chem. 2020 Jan;94:103378. [Content Brief]
[3]. Dhaneshwar SS. Colon-specific prodrugs of 4-aminosalicylic acid for inflammatory bowel disease. World J Gastroenterol. 2014 Apr 7;20(13):3564-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Aminosalicylic acid hemicalcium Related Classifications
HY-22252 Related Classifications
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