5-HT7R antagonist 3
5-HT7R antagonist 3 (Compound 6.4) is a selective 5-HT7R antagonist (Ki: 8 nM), with Ki of 511 nM (D2), 8930 nM (5-HT1A) and 5786 nM (5-HT2A), respectively. 5-HT7R antagonist 3 possesses antidepressant and anxiolytic effects in mice.
For research use only. We do not sell to patients.
- CAS No.: 1887043-58-4
- Formula: C30H33FN4O3
- Molecular Weight:516.61
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
5-HT7 Receptor 8 nM (Ki) |
5-HT1A Receptor |
5-HT2A Receptor |
5-HT7 Receptor |
5-HT1A Receptor 8930 nM (Ki) |
5-HT2A Receptor 5786 nM (Ki) |
D2 Receptor 511 nM (Ki) |
5-HT7R antagonist 3 (1 pM-1 μM) inhibits cAMP production in cells stably expressing human 5-HT, with IC50 of 113 nM, Kb of 14 nM [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male BalbC mice weighing 20-25 g[1]
-
Dosage:0, 0.63, 1.25, 2.5, 5, 10 mg/kg
-
Administration:Intraperitoneal injection (i.p.)
-
Result:Showed significant antidepressant effects in forced swim test (FST) at a dose of 2.5 mg/kg, reducing immobility time by 29%.
Showed anxiolytic activity in four-plate test (FPT) at doses of 1.25, 2.5 and 10 mg/kg.
Reduced spontaneous locomotion during the 60-minute observation period.
Chemical Information
-
CAS No. 1887043-58-4
-
Molecular Weight 516.61
-
Formula C30H33FN4O3
-
SMILES
O=C1N(C[C@H](O)CN2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C([C@](C)(C5=CC=C(F)C=C5)N1)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-HT7R antagonist 3 Related Classifications
HY-159942 Related Classifications
Powered by Bioz