5-Hydroxytryptamine creatinine sulfate monohydrate
Based on 1 Customer Validation
5-Hydroxytryptamine creatinine sulfate monohydrate is a 5-HT receptor agonist and amine oxidase substrate that acts through multiple physiological responses, including induction of vasoconstriction, pressor effects, acceleration of platelet potassium exchange, and endothelium-dependent relaxation, and can serve as a radiolabeled substrate for organelle uptake assays. 5-Hydroxytryptamine creatinine sulfate monohydrate can be used in research on burns, tourniquet and botulinum shock.
For research use only. We do not sell to patients.
- Purity : 99.87%
- CAS No.: 61-47-2
- Formula: C14H23N5O7S
- Molecular Weight:405.43
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
5-Hydroxytryptamine creatinine sulfate (1 mg/cc) has no effect on the isolated bovine blood coagulation system, indicating that it does not possess thrombin-like, thromboplastin-like, or prothrombin conversion accelerator activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Human subjects (healthy or with various diseases without elevated venous pressure; one with ventricular septal defect and right-to-left shunt)[2]
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Dosage:0.15 γ/5 min; 1.5 γ/5 min; 15 γ/5 min; 45 γ total; 330 γ/min (30 min); 330 γ/min (15 min); 1,000 γ; 200 γ
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Administration:i.v.; intra-arterial
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Result:Induced negligible venopressor effect at 0.15 γ/5 min.
Induced significant elevation of local venous pressure lasting at least 5 minutes after infusion at 1.5 γ/5 min.
Induced more pronounced and sustained venopressor response at 15 γ/5 min.
Produced no systemic venopressor response when a total of 45 γ was injected in 15 subjects (15 γ/5 min).
Produced progressively more pronounced venopressor responses with repeated infusions of 1.5 γ/5 min; local severe pain prevented continuation beyond 3 times.
Reached maximum venopressor effect quickly during 30-minute infusion of 330 γ/min (total 10,000 γ); further administration maintained but did not significantly enhance the effect; no elevation of systemic venous or arterial pressure.
In a healthy 16-year-old girl receiving 1,000 γ i.v. in 1 minute, caused pain at injection site within 15 seconds and flushing sensation limited to face and neck for 2 to 3 minutes; arterial blood pressure rose from 130/64 to 150/110 mm Hg within 1 minute and returned to normal within 2 minutes; no rise of systemic venous pressure.
In a 50-year-old male receiving 1,000 γ intra-arterially, caused severe but fleeting pain immediately; radial pulse could not be felt for 5 minutes; after blanching, skin of volar and dorsal surface of hand appeared flushed for longer than 30 minutes; pressure rose from 117/80 to 130/86 mm Hg at end of injection, dropped to 100/60 mm Hg at end of 5 minutes, returned to normal within 10 minutes; pressure in homolateral vein rose from 65 to 280 mm H2O, with readings after 5, 10, 20, and 25 minutes of 190, 155, 120, and 75 mm H2O respectively; no rise of pressure in contralateral vein.
In a patient with ventricular septal defect receiving 200 γ i.v. in one minute, induced immediate generalized flushing sensation and numbness; arterial pressure rose from 110/80 to 125/100 mm Hg for about 5 minutes; venous pressure in opposite arm remained unchanged.
Chemical Information
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CAS No. 61-47-2
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Appearance Solid
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Molecular Weight 405.43
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Formula C14H23N5O7S
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Color White to off-white
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SMILES
NCCC1=CNC2=CC=C(O)C=C12.N=C(N(C3)C)NC3=O.O=S(O)(O)=O.[H]O[H]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
0.1 M HCl : 20 mg/mL (49.33 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
DMSO : 11.67 mg/mL (28.78 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / 0.1 M HCl | 1 mM | 2.4665 mL | 12.3326 mL | 24.6652 mL | 61.6629 mL |
| 5 mM | 0.4933 mL | 2.4665 mL | 4.9330 mL | 12.3326 mL | |
| 10 mM | 0.2467 mL | 1.2333 mL | 2.4665 mL | 6.1663 mL | |
| 15 mM | 0.1644 mL | 0.8222 mL | 1.6443 mL | 4.1109 mL | |
| 20 mM | 0.1233 mL | 0.6166 mL | 1.2333 mL | 3.0831 mL | |
| 25 mM | 0.0987 mL | 0.4933 mL | 0.9866 mL | 2.4665 mL | |
| 0.1 M HCl | 30 mM | 0.0822 mL | 0.4111 mL | 0.8222 mL | 2.0554 mL |
| 40 mM | 0.0617 mL | 0.3083 mL | 0.6166 mL | 1.5416 mL |
5-Hydroxytryptamine creatinine sulfate monohydrate Related Classifications
HY-W010973 Related Classifications
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Keywords
- 5-Hydroxytryptamine creatinine sulfate
- 61-47-2
- Endogenous Metabolite
- 5-HT Receptor
- endothelial 5-HT receptor
- 5-HT receptor agonist
- arterial vasopressor
- histamine shock
- platelet dense organelles
- amine oxidase substrate
- rat stomach strip smooth muscle
- endothelium-dependent relaxation of rabbit jugular vein
- vasoconstriction of terminal arterioles and capillaries
- local venopressor effects
- Inhibitor
- inhibitor
- inhibit