Art. -Nr.: HY-116934

5-Pentadecylresorcinol

(Synonyms: Adipostatin A)

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

5-Pentadecylresorcinol (Adipostatin A) is a glycerol-3-phosphate dehydrogenase (GPDH) inhibitor with an IC₅₀ of 4.1 μM. Adipostatin A shows good larvicidal activity against Aedes aegypti.

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Reinheit: 99.31%
CAS. Nr.: 3158-56-3
Formel: C₂₁H₃₆O₂
Molecular Weight:320.51

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

5-Pentadecylresorcinol Chemical Structure

CAS. Nr.: 3158-56-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	1.31 μM Compound: 9	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay Cytotoxicity against human A2780 cells after 96 hrs by MTT assay	[PMID: 17125236]
A549	ED₅₀	2.37 μg/mL Compound: 6	Cytotoxicity against human A549 cells after 7 days Cytotoxicity against human A549 cells after 7 days	[PMID: 8201311]
A549	IC₅₀	1.43 μM Compound: 9	Cytotoxicity against human A549 cells after 96 hrs by MTT assay Cytotoxicity against human A549 cells after 96 hrs by MTT assay	[PMID: 17125236]
Bel-7402	IC₅₀	1.93 μM Compound: 9	Cytotoxicity against human Bel-7402 cells after 96 hrs by MTT assay Cytotoxicity against human Bel-7402 cells after 96 hrs by MTT assay	[PMID: 17125236]
BGC-823	IC₅₀	1.74 μM Compound: 9	Cytotoxicity against human BGC-823 cells after 96 hrs by MTT assay Cytotoxicity against human BGC-823 cells after 96 hrs by MTT assay	[PMID: 17125236]
BT-20	IC₅₀	6.25 μg/mL Compound: Page3979, R5C1	Growth inhibition of human BT20 cells Growth inhibition of human BT20 cells	[PMID: 21658963]
FM3A	IC₅₀	2.8 μM Compound: Page3979, R5C1	Growth inhibition of mouse FM3A cells Growth inhibition of mouse FM3A cells	[PMID: 21658963]
HCT-8	IC₅₀	1.48 μM Compound: 9	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay	[PMID: 17125236]
HeLa	IC₅₀	4.02 μg/mL Compound: Page3979, R5C1	Growth inhibition of human HeLa cells Growth inhibition of human HeLa cells	[PMID: 21658963]
HT-29	ED₅₀	3.25 μg/mL Compound: 6	Cytotoxicity against human HT-29 cells after 7 days Cytotoxicity against human HT-29 cells after 7 days	[PMID: 8201311]
MCF7	ED₅₀	2.41 μg/mL Compound: 6	Cytotoxicity against human MCF7 cells after 7 days Cytotoxicity against human MCF7 cells after 7 days	[PMID: 8201311]
MCF7	IC₅₀	37 μM Compound: 13	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 17243726]
MCF7	IC₅₀	37 μM Compound: Page3979, R5C1	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	[PMID: 21658963]
NCI-H460	IC₅₀	34.2 μM Compound: 13	Cytotoxicity against human NCI-H460 cells Cytotoxicity against human NCI-H460 cells	[PMID: 17243726]
NCI-H460	IC₅₀	34.2 μM Compound: Page3979, R5C1	Growth inhibition of human NCI-H460 cells Growth inhibition of human NCI-H460 cells	[PMID: 21658963]
SF-268	IC₅₀	39.8 μM Compound: 13	Cytotoxicity against human SF268 cells Cytotoxicity against human SF268 cells	[PMID: 17243726]

In Vitro

5-Pentadecylresorcinol (Adipostatin A) prevents triglyceride accumulation in 3T3-L1 cells at a concentration of the microM level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3158-56-3
Appearance Solid
Molecular Weight 320.51
Formel C₂₁H₃₆O₂
Color Off-white to light yellow
SMILES

OC1=CC(O)=CC(CCCCCCCCCCCCCCC)=C1
Synonyms

Adipostatin A
Structure Classification
- Phenols
- Polyphenols
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Mol Cell

Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation. [Abstract]

2024 Feb 15;84(4):744-759.e6. PMID: 38266638
Cell Death Differ

A neutrophil-intrinsic CKLF1-PKM2 axis drives glycolytic flux for de novo DAG synthesis and pro-inflammatory ROS production. [Abstract]

2026 May 12. PMID: 42120940

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (312.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1200 mL

15.6001 mL

31.2003 mL

5 mM

0.6240 mL

3.1200 mL

6.2401 mL

10 mM

0.3120 mL

1.5600 mL

3.1200 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 1.25 mg/mL (3.90 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 1.25 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (3.90 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tsuge, et al. Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase. J Antibiot (Tokyo). 1992 Jun;45(6):886-91. [Content Brief]

[2]. Micheline Soares Costa Oliveira, et al. Antioxidant, larvicidal and antiacetylcholinesterase activities of cashew nut shell liquid constituents. Acta Trop. 2011 Mar;117(3):165-70. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1200 mL	15.6001 mL	31.2003 mL	78.0007 mL
	5 mM	0.6240 mL	3.1200 mL	6.2401 mL	15.6001 mL
	10 mM	0.3120 mL	1.5600 mL	3.1200 mL	7.8001 mL
	15 mM	0.2080 mL	1.0400 mL	2.0800 mL	5.2000 mL
	20 mM	0.1560 mL	0.7800 mL	1.5600 mL	3.9000 mL
	25 mM	0.1248 mL	0.6240 mL	1.2480 mL	3.1200 mL
	30 mM	0.1040 mL	0.5200 mL	1.0400 mL	2.6000 mL
	40 mM	0.0780 mL	0.3900 mL	0.7800 mL	1.9500 mL
	50 mM	0.0624 mL	0.3120 mL	0.6240 mL	1.5600 mL
	60 mM	0.0520 mL	0.2600 mL	0.5200 mL	1.3000 mL
	80 mM	0.0390 mL	0.1950 mL	0.3900 mL	0.9750 mL
	100 mM	0.0312 mL	0.1560 mL	0.3120 mL	0.7800 mL

Keywords

5-Pentadecylresorcinol

2 Cited Publications

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5-Pentadecylresorcinol

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Publications Citing Use of MedChemExpress (MCE) 5-Pentadecylresorcinol

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

5-Pentadecylresorcinol

Anti-Infection Compound Library

Natural Product Library

Anti-Cancer Compound Library

Lipid Compound Library

Phenols Library

Traditional Chinese Medicine Active Compound Library

Food-Sourced Compound Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Metabolite Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) 5-Pentadecylresorcinol

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

5-Pentadecylresorcinol Related Classifications

HY-116934 Related Classifications