8-Cyclopentyl-1,3-dimethylxanthine
Based on 1 publication(s) in Google Scholar
8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) is a selective adenosine A1 receptor antagonist with Kis of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 35873-49-5
- Formula: C12H16N4O2
- Molecular Weight:248.28
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 8-Cyclopentyl-1,3-dimethylxanthine
MoreAll Adenosine Receptor Isoforms
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Biological Activity
Ki: 10.9 nM (A1 receptor), 1440 nM (A2 receptor)[1]
Chemical Information
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CAS No. 35873-49-5
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Appearance Solid
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Molecular Weight 248.28
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Formula C12H16N4O2
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Color White to off-white
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SMILES
O=C(N1C)N(C)C2=C(N=C(C3CCCC3)N2)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Toxicol Lett
SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers. [Abstract]2023 Oct 1:388:48-55. PMID: 37806366
Solvent & Solubility
DMSO : 20 mg/mL (80.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0277 mL | 20.1386 mL | 40.2771 mL | 100.6928 mL |
| 5 mM | 0.8055 mL | 4.0277 mL | 8.0554 mL | 20.1386 mL | |
| 10 mM | 0.4028 mL | 2.0139 mL | 4.0277 mL | 10.0693 mL | |
| 15 mM | 0.2685 mL | 1.3426 mL | 2.6851 mL | 6.7129 mL | |
| 20 mM | 0.2014 mL | 1.0069 mL | 2.0139 mL | 5.0346 mL | |
| 25 mM | 0.1611 mL | 0.8055 mL | 1.6111 mL | 4.0277 mL | |
| 30 mM | 0.1343 mL | 0.6713 mL | 1.3426 mL | 3.3564 mL | |
| 40 mM | 0.1007 mL | 0.5035 mL | 1.0069 mL | 2.5173 mL | |
| 50 mM | 0.0806 mL | 0.4028 mL | 0.8055 mL | 2.0139 mL | |
| 60 mM | 0.0671 mL | 0.3356 mL | 0.6713 mL | 1.6782 mL | |
| 80 mM | 0.0503 mL | 0.2517 mL | 0.5035 mL | 1.2587 mL |
8-Cyclopentyl-1,3-dimethylxanthine Related Classifications
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