8-Cyclopentyl-1,3-dimethylxanthine

Cat. No.: HY-W011955 Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

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8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) is a selective adenosine A1 receptor antagonist with K_is of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively.

For research use only. We do not sell to patients.

8-Cyclopentyl-1,3-dimethylxanthine Chemical Structure

CAS No. : 35873-49-5

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5 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 43	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
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100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE 8-Cyclopentyl-1,3-dimethylxanthine

•Toxicol Lett. 2023 Oct 6:S0378-4274(23)01056-1. [Abstract]

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Adenosine A₁ receptor (A₁R) Adenosine A_2A receptor (A_2AR) Adenosine A_2B receptor (A_2BR) Adenosine A₃ receptor (A₃R)

Biological Activity
Purity & Documentation
References
Customer Review

Description

8-Cyclopentyl-1,3-dimethylxanthine (Compound 2a) is a selective adenosine A1 receptor antagonist with K_is of 10.9 nM and 1440 nM for A1 receptor and A2 receptor, respectively^[1].

IC₅₀ & Target

Ki: 10.9 nM (A1 receptor), 1440 nM (A2 receptor)^[1]

Molecular Weight

248.28

Formula

C₁₂H₁₆N₄O₂

CAS No.

35873-49-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C)N(C)C2=C(N=C(C3CCCC3)N2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (80.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0277 mL	20.1386 mL	40.2771 mL
5 mM	0.8055 mL	4.0277 mL	8.0554 mL
10 mM	0.4028 mL	2.0139 mL	4.0277 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (249 KB) HNMR (238 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. K A Jacobson, et al. Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. J Med Chem. 1989 Aug;32(8):1873-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0277 mL	20.1386 mL	40.2771 mL	100.6928 mL
	5 mM	0.8055 mL	4.0277 mL	8.0554 mL	20.1386 mL
	10 mM	0.4028 mL	2.0139 mL	4.0277 mL	10.0693 mL
	15 mM	0.2685 mL	1.3426 mL	2.6851 mL	6.7129 mL
	20 mM	0.2014 mL	1.0069 mL	2.0139 mL	5.0346 mL
	25 mM	0.1611 mL	0.8055 mL	1.6111 mL	4.0277 mL
	30 mM	0.1343 mL	0.6713 mL	1.3426 mL	3.3564 mL
	40 mM	0.1007 mL	0.5035 mL	1.0069 mL	2.5173 mL
	50 mM	0.0806 mL	0.4028 mL	0.8055 mL	2.0139 mL
	60 mM	0.0671 mL	0.3356 mL	0.6713 mL	1.6782 mL
	80 mM	0.0503 mL	0.2517 mL	0.5035 mL	1.2587 mL