Anemarrhenasaponin I
Based on 4 publication(s) in Google Scholar
Anemarrhenasaponin I, a traditional Chinese medicine, shows remarkable inhibiting effect on platelet aggregation.
For research use only. We do not sell to patients.
- Purity: 99.48%
- CAS No.: 163047-21-0
- Formula: C39H66O14
- Molecular Weight:758.93
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Anemarrhenasaponin I
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Customer Validation & Images
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WB
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Cell Proliferation/Viability Assay
Biological Activity
Six steroidal saponins are isolated from Anemarrhena asphodeloides Bunge (Liliaceae), a traditional chinese medicine, and named Anemarrhenasaponin I (An-I), Anemarrhenasaponin Ia (An-Ia), Timosaponin B-I (TB-I), Timosaponin B-II (TB-II), Timosaponin B-III (TB-III), and Timosaponin A-III (TA-III)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 163047-21-0
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Appearance Solid
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Molecular Weight 758.93
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Formula C39H66O14
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Color White to off-white
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SMILES
C[C@@]12[C@]([C@@H](O)[C@@]3([H])[C@]2([H])[C@@H](C(CCC(C)C)(O)O3)C)([H])[C@@]4([H])[C@]([C@@]5([C@](C[C@@H](O[C@@]6([H])[C@@H]([C@H]([C@@H](O)[C@@H](CO)O6)O)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)CC5)([H])CC4)C)([H])CC1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (4)
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Journal Impact Factor
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Most Recent
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Chin Med
Therapeutic potential of Sheng-Xian-Tang in doxorubicin-induced chronic heart failure by regulation of phenylalanine metabolism disruption. [Abstract]2026 Jan 12;21(1):29. PMID: 41527105 -
Anemarrhenasaponin I purchased from MedChemExpress. Usage Cited in: Oncologie. 2023 Mar 10.
Anemarrhenasaponin I (An-I; 25, 50, 75 μM) downregulates the expression level of GLI1 in SKOV3 cells in a concentration-dependent manner.
Anemarrhenasaponin I purchased from MedChemExpress. Usage Cited in: Oncologie. 2023 Mar 10.
Both Anemarrhenasaponin I (An-I; 25 μM; 24 h) and GANT61 (20 μM; 24 h) can suppress the clonogenic ability of SKOV3 cells remarkably.
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Biol Pharm Bull
Timosaponin AIII Disrupts Cell-Extracellular Matrix Interactions through the Inhibition of Endocytic Pathways. [Abstract]2024;47(10):1648-1656. PMID: 39401908 -
Solvent & Solubility
DMSO : ≥ 50 mg/mL (65.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.29 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3176 mL | 6.5882 mL | 13.1764 mL | 32.9411 mL |
| 5 mM | 0.2635 mL | 1.3176 mL | 2.6353 mL | 6.5882 mL | |
| 10 mM | 0.1318 mL | 0.6588 mL | 1.3176 mL | 3.2941 mL | |
| 15 mM | 0.0878 mL | 0.4392 mL | 0.8784 mL | 2.1961 mL | |
| 20 mM | 0.0659 mL | 0.3294 mL | 0.6588 mL | 1.6471 mL | |
| 25 mM | 0.0527 mL | 0.2635 mL | 0.5271 mL | 1.3176 mL | |
| 30 mM | 0.0439 mL | 0.2196 mL | 0.4392 mL | 1.0980 mL | |
| 40 mM | 0.0329 mL | 0.1647 mL | 0.3294 mL | 0.8235 mL | |
| 50 mM | 0.0264 mL | 0.1318 mL | 0.2635 mL | 0.6588 mL | |
| 60 mM | 0.0220 mL | 0.1098 mL | 0.2196 mL | 0.5490 mL |
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