1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA/RNA Synthesis
    SARS-CoV
    Filovirus
  3. Galidesivir

Galidesivir (Synonyms: BCX4430; Immucillin-A)

製品番号: HY-18649A 純度: 99.29%
取扱説明書

Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM.

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Galidesivir 構造式

Galidesivir 構造式

CAS 番号 : 249503-25-1

容量 価格(税別) 在庫状況 数量
1 mg USD 600 在庫あり
Estimated Time of Arrival: December 31
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カスタマーレビュー

Based on 4 publication(s) in Google Scholar

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製品説明

Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM[1][2][3].

IC50 & Target

RdRp

体外実験

Cellular kinases phosphorylate Galidesivir (BCX4430) to a triphosphate that mimics ATP; viral RNA polymerases incorporate the drug's monophosphate nucleotide into the growing RNA chain, causing premature chain termination[1].
Galidesivir effectively inhibits the infection of Vero cells with YFV. The EC50 determined by the neutral red uptake assay is 8.3 μg/ml (24.5 μM)[3].

体内実験

Galidesivir (BCX4430) is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir has demonstrated pronounced efficacy[1].
Galidesivir (4 mg/kg; i.p.; twice daily for 7 days) is effectively in a hamster model of yellow fever (YF)[4].

Animal Model: Female Syrian golden hamsters (hamsters infected with YF virus)[4]
Dosage: 4 mg/kg of body weight
Administration: I.p.; twice daily for 7 days
Result: Significantly improved the survival of hamsters infected with YFV.
臨床実験
分子量

265.27

分子式

C₁₁H₁₅N₅O₃

CAS 番号

249503-25-1

SMILES
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 1.53 mg/mL (5.77 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7697 mL 18.8487 mL 37.6974 mL
5 mM 0.7539 mL 3.7697 mL 7.5395 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
参考文献
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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GalidesivirBCX4430Immucillin-ABCX 4430BCX-4430DNA/RNA SynthesisSARS-CoVFilovirusSARS coronavirusadenosinenucleosideanalogvirusinfectionpathogenicCOVID-19Inhibitorinhibitorinhibit

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製品名:
Galidesivir
製品番号:
HY-18649A
数量:
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