BD-1047 dihydrobromide
Based on 13 publication(s) in Google Scholar
BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors. BD-1047 dihydrobromide attenuates Apomorphine (HY-12723)-induced climbing and Phencyclidine-induced head twitches.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.45%
- CAS No.: 138356-21-5
- Formule: C13H22Br2Cl2N2
- Masse moléculaire:437.04
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BD-1047 dihydrobromide
More- Neural Regen Res. 2025 Aug 1;20(8):2325-2336. [Abstract]
- Mol Med. 2022 Aug 3;28(1):87. [Abstract]
- Cell Rep. 2023 Jan 31;42(1):112011. [Abstract]
- Br J Pharmacol. 2026 Aug;183(15):4178-4195. [Abstract]
- Br J Pharmacol. 2026 Jul 15.
- Life Sci. 2020 Sep 15:257:118047. [Abstract]
- Eur J Pharmacol. 2023 May 5:946:175647. [Abstract]
- Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]
- Int Immunopharmacol. 2023 Apr:117:109907. [Abstract]
- Mol Neurobiol. 2025 Jun 1. [Abstract]
- Eur J Med Res. 2025 Oct 30;30(1):1041. [Abstract]
- Behav Brain Res. 2025 Apr 27:484:115493. [Abstract]
- Int J Gen Med. 2025 Apr 4:18:1917-1931. [Abstract]
Customer Validation & Images
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Cell Proliferation/Viability Assay
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WB
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Histological Imaging/Staining
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Cell Imaging/Staining
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WB
Voir tous les produits spécifiques à Isoform Sigma Receptor
More
Activité biologique
Description
IC50 & Target
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Sigma 1 Receptor |
In Vitro
BD-1047 (dihydrobromide) prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells[2].
BD-1047 (dihydrobromide) attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine)[3].
BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Albino Swiss mice (50 days old, 25–28 g)[1]
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Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
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Administration:Intraperitoneal injection
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Result:Decreased the APO-induced climbing at the dose of 10 mg/kg in mice.
Chemical Information
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CAS No. 138356-21-5
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Appearance Solid
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Masse moléculaire 437.04
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Formule C13H22Br2Cl2N2
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Color White to off-white
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SMILES
CN(C)CCN(CCC1=CC=C(Cl)C(Cl)=C1)C.[H]Br.[H]Br
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (13)
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Journal Impact Factor
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Most Recent
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Neural Regen Res
Hypidone hydrochloride (YL-0919) ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation. [Abstract]2025 Aug 1;20(8):2325-2336. PMID: 39359091
BD-1047 dihydrobromide purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2025 Aug 1;20(8):2325-2336. [Abstract]
Viability of cells pretreated with or without H2O2, YL, and BD-1047 (BD) for 1 hour.
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Mol Med
Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis. [Abstract]2022 Aug 3;28(1):87. PMID: 35922746 -
Cell Rep
Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions. [Abstract]2023 Jan 31;42(1):112011. PMID: 36656708 -
Br J Pharmacol
Requirement of sigma-1 receptor (Sig-1R) for boosting the gamma oscillations in the medial prefrontal cortex (mPFC). [Abstract]2026 Aug;183(15):4178-4195. PMID: 42025290 -
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Life Sci
Chronic stimulation of the sigma-1 receptor ameliorates ventricular ionic and structural remodeling in a rodent model of depression. [Abstract]2020 Sep 15:257:118047. PMID: 32629001 -
Eur J Pharmacol
Sigma-1 receptor agonist properties that mediate the fast-onset antidepressant effect of hypidone hydrochloride (YL-0919). [Abstract]2023 May 5:946:175647. PMID: 36898424 -
Int Immunopharmacol
Activation of sigma-1 receptor ameliorates sepsis-induced myocardial injury by mediating the Nrf2/HO1 signaling pathway to attenuate mitochondrial oxidative stress. [Abstract]2024 Jan 25:127:111382. PMID: 38141412
BD-1047 dihydrobromide purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]
Western blot results showed that Flv and BD1047 (0.3 mg/kg) alone had no effect on normal rats.
BD-1047 dihydrobromide purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]
BD1047 (0.3 mg/kg) S1R activation improved myocardial contractility in CLP rats. HE staining showed that S1R activation led to denser myocardial packing and reduced sepsis-induced damage.
BD-1047 dihydrobromide purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]
ROS immunofluorescence staining showed that S1R activation of BD1047 (5 μM) reduced ROS production in myocardial tissue.
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Int Immunopharmacol
Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1. [Abstract]2023 Apr:117:109907. PMID: 36827915
BD-1047 dihydrobromide purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Apr:117:109907. [Abstract]
BD-1047 dihydrobromide significantly decreases the expression of GFAP in astrocytes.
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Mol Neurobiol
Sigma-1 Receptor Activation Alleviates iBRB Dysfunction after I/R Injury by Inhibiting Endoplasmic Reticulum Stress-Dependent Autophagy. [Abstract]2025 Jun 1. PMID: 40450632 -
Eur J Med Res
Investigation of the mechanism by which sigma-1 receptor protein mediates the IRE1-XBP-1s pathway to alleviate cerebral ischemia-reperfusion injury. [Abstract]2025 Oct 30;30(1):1041. PMID: 41163082 -
Behav Brain Res
Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes. [Abstract]2025 Apr 27:484:115493. PMID: 39986614 -
Int J Gen Med
Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury. [Abstract]2025 Apr 4:18:1917-1931. PMID: 40201929
Solvant et solubilité
In Vitro:
DMSO : 25 mg/mL (57.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (57.20 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.72 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.72 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (76.26 mM); Clear solution; Need ultrasonic
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (273 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.2881 mL | 11.4406 mL | 22.8812 mL | 57.2030 mL |
| 5 mM | 0.4576 mL | 2.2881 mL | 4.5762 mL | 11.4406 mL | |
| 10 mM | 0.2288 mL | 1.1441 mL | 2.2881 mL | 5.7203 mL | |
| 15 mM | 0.1525 mL | 0.7627 mL | 1.5254 mL | 3.8135 mL | |
| 20 mM | 0.1144 mL | 0.5720 mL | 1.1441 mL | 2.8602 mL | |
| 25 mM | 0.0915 mL | 0.4576 mL | 0.9152 mL | 2.2881 mL | |
| 30 mM | 0.0763 mL | 0.3814 mL | 0.7627 mL | 1.9068 mL | |
| 40 mM | 0.0572 mL | 0.2860 mL | 0.5720 mL | 1.4301 mL | |
| 50 mM | 0.0458 mL | 0.2288 mL | 0.4576 mL | 1.1441 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BD-1047 dihydrobromide Related Classifications
HY-16996A Related Classifications
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