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Cat. No.: HY-16996

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BD-1047

12 Cited Publications

Customer Review

Based on 12 publication(s) in Google Scholar

BD-1047 is a selective functional antagonist of sigma receptors. BD-1047 attenuates Apomorphine (HY-12723)-induced climbing and Phencyclidine-induced head twitches.

For research use only. We do not sell to patients.

CAS No.: 138356-20-4
Formula: C₁₃H₂₀Cl₂N₂
Molecular Weight:275.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BD-1047 Chemical Structure

CAS No.: 138356-20-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

BD-1047 is a selective functional antagonist of sigma receptors. BD-1047 attenuates Apomorphine (HY-12723)-induced climbing and Phencyclidine-induced head twitches^[1].

All Sigma Receptor Isoforms :

Chemical Information

CAS No. 138356-20-4
Molecular Weight 275.22
Formula C₁₃H₂₀Cl₂N₂
SMILES

CN(C)CCN(CCC1=CC=C(Cl)C(Cl)=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (12)

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Neural Regen Res

Hypidone hydrochloride (YL-0919) ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation. [Abstract]

2025 Aug 1;20(8):2325-2336. PMID: 39359091

BD-1047 purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2025 Aug 1;20(8):2325-2336. [Abstract]

Viability of cells pretreated with or without H2O2, YL, and BD-1047 (BD) for 1 hour.
Mol Med

Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis. [Abstract]

2022 Aug 3;28(1):87. PMID: 35922746
Cell Rep

Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions. [Abstract]

2023 Jan 31;42(1):112011. PMID: 36656708
Br J Pharmacol

Requirement of sigma-1 receptor (Sig-1R) for boosting the gamma oscillations in the medial prefrontal cortex (mPFC). [Abstract]

2026 Aug;183(15):4178-4195. PMID: 42025290
Life Sci

Chronic stimulation of the sigma-1 receptor ameliorates ventricular ionic and structural remodeling in a rodent model of depression. [Abstract]

2020 Sep 15:257:118047. PMID: 32629001
Eur J Pharmacol

Sigma-1 receptor agonist properties that mediate the fast-onset antidepressant effect of hypidone hydrochloride (YL-0919). [Abstract]

2023 May 5:946:175647. PMID: 36898424
Int Immunopharmacol

Activation of sigma-1 receptor ameliorates sepsis-induced myocardial injury by mediating the Nrf2/HO1 signaling pathway to attenuate mitochondrial oxidative stress. [Abstract]

2024 Jan 25:127:111382. PMID: 38141412

BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]

Western blot results showed that Flv and BD1047 (0.3 mg/kg) alone had no effect on normal rats.

BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]

BD1047 (0.3 mg/kg) S1R activation improved myocardial contractility in CLP rats. HE staining showed that S1R activation led to denser myocardial packing and reduced sepsis-induced damage.

BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]

ROS immunofluorescence staining showed that S1R activation of BD1047 (5 μM) reduced ROS production in myocardial tissue.
Int Immunopharmacol

Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1. [Abstract]

2023 Apr:117:109907. PMID: 36827915

BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Apr:117:109907. [Abstract]

BD-1047 dihydrobromide significantly decreases the expression of GFAP in astrocytes.
Mol Neurobiol

Sigma-1 Receptor Activation Alleviates iBRB Dysfunction after I/R Injury by Inhibiting Endoplasmic Reticulum Stress-Dependent Autophagy. [Abstract]

2025 Jun 1. PMID: 40450632
Eur J Med Res

Investigation of the mechanism by which sigma-1 receptor protein mediates the IRE1-XBP-1s pathway to alleviate cerebral ischemia-reperfusion injury. [Abstract]

2025 Oct 30;30(1):1041. PMID: 41163082
Behav Brain Res

Sigma-1 receptor agonist PRE-084 increases BDNF by activating the ERK/CREB pathway to rescue learning and memory impairment caused by type II diabetes. [Abstract]

2025 Apr 27:484:115493. PMID: 39986614
Int J Gen Med

Sigma-1 Receptor Rescues Autophagy Through AMPK/mTOR Signaling Pathway in Sepsis-Induced Acute Kidney Injury. [Abstract]

2025 Apr 4:18:1917-1931. PMID: 40201929

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Skuza G, et al. Effect of BD 1047, a sigma1 receptor antagonist, in the animal models predictive of antipsychotic activity. Pharmacol Rep. 2006 Sep-Oct;58(5):626-35. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Publications (12)
Purity & Documentation
References

1/16
1/16

BD-1047 purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2025 Aug 1;20(8):2325-2336. [Abstract]

Customer Validation
Viability of cells pretreated with or without H2O2, YL, and BD-1047 (BD) for 1 hour.
1/16

BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]

Customer Validation
Western blot results showed that Flv and BD1047 (0.3 mg/kg) alone had no effect on normal rats.
1/16

BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]

Customer Validation
BD1047 (0.3 mg/kg) S1R activation improved myocardial contractility in CLP rats. HE staining showed that S1R activation led to denser myocardial packing and reduced sepsis-induced damage.
1/16

BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 Jan 25:127:111382. [Abstract]

Customer Validation
ROS immunofluorescence staining showed that S1R activation of BD1047 (5 μM) reduced ROS production in myocardial tissue.
1/16

BD-1047 purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Apr:117:109907. [Abstract]

Customer Validation
BD-1047 dihydrobromide significantly decreases the expression of GFAP in astrocytes.

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BD-1047

Publications Citing Use of MedChemExpress (MCE) BD-1047

All Sigma Receptor Isoforms