1. Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  2. nAChR Endogenous Metabolite
  3. Choline chloride

Choline chloride 

Cat. No.: HY-B1337 Purity: ≥98.0%
COA Handling Instructions

Choline chloride is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders.

For research use only. We do not sell to patients.

Choline chloride Chemical Structure

Choline chloride Chemical Structure

CAS No. : 67-48-1

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 66 In-stock
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10 mM * 1 mL in DMSO USD 66 In-stock
Solid
100 mg USD 60 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Choline chloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Choline chloride is an essential nutrient that activates alpha7 nicotinic receptors and has analgesic and anti-inflammatory activity. Glycerophosphoinositol choline can affect diseases such as liver disease, atherosclerosis and neurological disorders[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Choline chloride (0 or 70 μM, 4 days) can effectively mitigate apoptosis and maintain cell viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Rat pheochromocytoma cells PC12
Concentration: 0 or 70 μM
Incubation Time: 4 days
Result: Showed the cell viability of 94% at 70 μM while cell viability of 83% at 0 μM.
Reduced the number of cells with DNA breaks (characteristic of apoptosis) by 8.5% at 70 μM compared to the no treatment group.
In Vivo

Choline chloride (s.c., 0.2 and 100 mg/kg/h, 24 or 48 hours) can reduce postoperative injurious reflexes and effectively decreases tumor necrosis factor (TNF) release from macrophages in female C57/Bl6 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Postoperative pain model of female C57/Bl6 mice[2]
Dosage: 0.2 and 100 mg/kg/h
Administration: Subcutaneous injection, 24 or 48 hours
Result: Reduced heat hypersensitivity after surgery with maximal efficacy after 48 h treatment and the ED50 value of choline dose was 1.7 mg/kg/h.
Reduced hypersensitivity to punctate mechanical stimuli 48 hours after infusion in a dose-dependent manner and with the ED50 value of 4.7 mg/kg/h but not 24 hours.
Clinical Trial
Molecular Weight

139.62

Formula

C5H14ClNO

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC[N+](C)(C)C.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 140 mg/mL (1002.72 mM)

H2O : ≥ 100 mg/mL (716.23 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.1623 mL 35.8115 mL 71.6230 mL
5 mM 1.4325 mL 7.1623 mL 14.3246 mL
10 mM 0.7162 mL 3.5811 mL 7.1623 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 130 mg/mL (931.10 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 3.5 mg/mL (25.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 3.5 mg/mL (25.07 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 3.5 mg/mL (25.07 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Choline chloride
Cat. No.:
HY-B1337
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