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  3. (S,R,S)-AHPC-PEG2-C4-Cl

(S,R,S)-AHPC-PEG2-C4-Cl (Synonyms: VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10)

Cat. No.: HY-103607 Purity: 98.79%
Handling Instructions

(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG2-C4-Cl Chemical Structure

(S,R,S)-AHPC-PEG2-C4-Cl Chemical Structure

CAS No. : 1835705-57-1

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Description

(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

IC50 & Target[1]

VHL

 

In Vitro

(S,R,S)-AHPC-PEG2-C4-Cl uses the VHL ligand[1]. The linker is 6-2-2. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. (S,R,S)-AHPC-PEG2-C4-Cl can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase[2].

Molecular Weight

651.26

Formula

C₃₂H₄₇ClN₄O₆S

CAS No.

1835705-57-1

SMILES

O=C([[email protected]]1N(C([[email protected]](C(C)(C)C)NC(COCCOCCCCCCCl)=O)=O)C[[email protected]](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (76.77 mM)

Ethanol : 50 mg/mL (76.77 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5355 mL 7.6774 mL 15.3548 mL
5 mM 0.3071 mL 1.5355 mL 3.0710 mL
10 mM 0.1535 mL 0.7677 mL 1.5355 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

(S,R,S)-AHPC-PEG2-C4-ClVH032-PEG2-C4-ClVHL Ligand-Linker Conjugates 7E3 ligase Ligand-Linker Conjugates 10PROTACProteolysis-targeting chimeraInhibitorinhibitorinhibit

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Product Name:
(S,R,S)-AHPC-PEG2-C4-Cl
Cat. No.:
HY-103607
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