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Fumarate hydratase-IN-2 sodium salt 

Cat. No.: HY-100005A Purity: >98.0%
Handling Instructions

Fumarate hydratase is an enzyme of the TCA cycle and cell-permeable inhibitors.

For research use only. We do not sell to patients.

Fumarate hydratase-IN-2 sodium salt Chemical Structure

Fumarate hydratase-IN-2 sodium salt Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 407 In-stock
Estimated Time of Arrival: December 31
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1920 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

.Fumarate hydratase is an enzyme of the TCA cycle and cell-permeable inhibitors (1) inhibition of fumarate hydratase can contribute to tumorigenicity in some cells. (2) The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target. Final biochemical studies confirmed dose-dependent, competitive inhibition of this enzyme (3) Chemical inhibition of fumarate hydratase renders cells highly dependent on glucose metabolism for survival.

Solvent & Solubility
In Vitro: 

DMSO : 10.66 mg/mL (24.20 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2703 mL 11.3515 mL 22.7030 mL
5 mM 0.4541 mL 2.2703 mL 4.5406 mL
10 mM 0.2270 mL 1.1352 mL 2.2703 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

440.47

Formula

C₂₅H₂₅N₂NaO₄

SMILES

O=C([O-])[[email protected]]1([[email protected]](CC(NC)=O)C2=O)C(N2CC(C=C3)=CC=C3C4=CC=CC=C4)=CCCC1.[Na+]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Fumarate hydratase-IN-2 sodium salt
Cat. No.:
HY-100005A
Quantity:

Fumarate hydratase-IN-2 sodium salt

Cat. No.: HY-100005A