Fumarate hydratase-IN-2 sodium salt

Cat. No.: HY-100005A Purity: 98.02%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fumarate hydratase-IN-2 sodium salt (compound 3) is a cell-permeable and competitive fumarate hydratase inhibitor (K_i=4.5 μM) with nutrient-dependent cytotoxicity .

For research use only. We do not sell to patients.

Fumarate hydratase-IN-2 sodium salt Chemical Structure

CAS No. : 2070009-45-7

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 264	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 264	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Fumarate hydratase-IN-2 sodium salt

•SLAS Discov. 2020 Jan;25(1):43-56. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Fumarate hydratase-IN-2 sodium salt (compound 3) is a cell-permeable and competitive fumarate hydratase inhibitor (K_i=4.5 μM) with nutrient-dependent cytotoxicity ^[1].

IC₅₀ & Target

Ki: 4.5 μM (Fumarate hydratase)^[1]

Molecular Weight

440.47

Formula

C₂₅H₂₅N₂NaO₄

CAS No.

2070009-45-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])[C@]1([C@H](CC(NC)=O)C2=O)C(N2CC(C=C3)=CC=C3C4=CC=CC=C4)=CCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 10.66 mg/mL (24.20 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 6.25 mg/mL (14.19 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2703 mL	11.3515 mL	22.7030 mL
5 mM	0.4541 mL	2.2703 mL	4.5406 mL
10 mM	0.2270 mL	1.1352 mL	2.2703 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.02%

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Data Sheet (275 KB) SDS (251 KB)

COA (253 KB) LCMS (261 KB)

Handling Instructions (2659 KB)

References

[1]. Takeuchi T et al. Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity. J Am Chem Soc. 2015 Jan 21;137(2):564-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.2703 mL	11.3515 mL	22.7030 mL	56.7576 mL
	5 mM	0.4541 mL	2.2703 mL	4.5406 mL	11.3515 mL
	10 mM	0.2270 mL	1.1352 mL	2.2703 mL	5.6758 mL
DMSO	15 mM	0.1514 mL	0.7568 mL	1.5135 mL	3.7838 mL
DMSO	20 mM	0.1135 mL	0.5676 mL	1.1352 mL	2.8379 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.