GRGDSP

Name: GRGDSP
Brand: MedChemExpress
SKU: HY-P0290
Rating: 5.0 (5 reviews)

Cat. No.: HY-P0290 Purity: 99.95%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

CAS No. : 91037-75-1

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 5 publication(s) in Google Scholar

Other Forms of GRGDSP:

GRGDSP TFA In-stock

5 Publications Citing Use of MCE GRGDSP

: GRGDSP purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Oct 17;12(17):7307-7318. [Abstract]; GRGDSP (1 mg/kg; inject at the injured area; single daily for 15 days) apparently reduces the densities of Mpz⁺, Ki67⁺and Sox10⁺ schwann cells in the injured area in the Dhh^cre/+;Ninj2^fl/fl mice.

: GRGDSP purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Oct 17;12(17):7307-7318. [Abstract]; Immunofluorescence staining images of NeuN and ITGB1 in the peri-infarct area. GRGDSP significantly downregulates rOPN-induced ITGB1.

: GRGDSP purchased from MedChemExpress. Usage Cited in: Theranostics. 2022 Oct 17;12(17):7307-7318. [Abstract]; GRGDSP decreases the expression of ITGB1 in the peri-infarct area.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

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View All Integrin Isoform Specific Products:

View All Isoforms

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
순도&문서
References
고객리뷰

제품 설명

GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.

IC₅₀ & Target

Integrin^[1]

In Vitro

It is demonstrated that transarterial infusion of GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro integrin-inhibitor which includes RGD-peptide). As a synthetic linear RGD peptide, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis^[1]. GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research. GRGDSP can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

587.58

화학식

C₂₂H₃₇N₉O₁₀

CAS No.

91037-75-1

Appearance

Solid

Color

White to off-white

Sequence

Gly-Arg-Gly-Asp-Ser-Pro

Sequence Shortening

GRGDSP

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

H₂O : 100 mg/mL (170.19 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7019 mL	8.5095 mL	17.0190 mL
5 mM	0.3404 mL	1.7019 mL	3.4038 mL
10 mM	0.1702 mL	0.8509 mL	1.7019 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.95%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (249 KB) HNMR (293 KB) RP-HPLC (206 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Qian J, et al. Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model. World J Gastroenterol. 2016 Jun 7;22(21):5042-9. [Content Brief]

[2]. Patel S, et al. Regulation of endothelial cell function by GRGDSP peptide grafted on interpenetrating polymers. J Biomed Mater Res A. 2007 Nov;83(2):423-33. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.7019 mL	8.5095 mL	17.0190 mL	42.5474 mL
	5 mM	0.3404 mL	1.7019 mL	3.4038 mL	8.5095 mL
	10 mM	0.1702 mL	0.8509 mL	1.7019 mL	4.2547 mL
	15 mM	0.1135 mL	0.5673 mL	1.1346 mL	2.8365 mL
	20 mM	0.0851 mL	0.4255 mL	0.8509 mL	2.1274 mL
	25 mM	0.0681 mL	0.3404 mL	0.6808 mL	1.7019 mL
	30 mM	0.0567 mL	0.2836 mL	0.5673 mL	1.4182 mL
	40 mM	0.0425 mL	0.2127 mL	0.4255 mL	1.0637 mL
	50 mM	0.0340 mL	0.1702 mL	0.3404 mL	0.8509 mL
	60 mM	0.0284 mL	0.1418 mL	0.2836 mL	0.7091 mL
	80 mM	0.0213 mL	0.1064 mL	0.2127 mL	0.5318 mL
	100 mM	0.0170 mL	0.0851 mL	0.1702 mL	0.4255 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

GRGDSP Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GRGDSP91037-75-1IntegrinInhibitorinhibitorinhibit

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GRGDSP

고객리뷰

Other Forms of GRGDSP:

GRGDSP Related Antibodies

5 Publications Citing Use of MCE GRGDSP

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Integrin Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

GRGDSP Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

GRGDSP Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report