1. GPCR/G Protein
  2. Leukotriene Receptor
  3. LM-1484

LM-1484 

Cat. No.: HY-101686
Handling Instructions

LM-1484 is an antagonist of CysLT1 receptor and displays a higher affinity for 3H-LTC4 sites.

For research use only. We do not sell to patients.

LM-1484 Chemical Structure

LM-1484 Chemical Structure

CAS No. : 197506-02-8

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Description

LM-1484 is an antagonist of CysLT1 receptor and displays a higher affinity for 3H-LTC4 sites.

IC50 & Target[1]

CysLT1

 

LTC4

 

In Vitro

LM-1484 (10 μM) induces the dissociation of 3H-LTD4, and is able to displace 3H-LTC4 from its binding sites[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

464.52

Formula

C₂₈H₂₄N₄O₃

CAS No.

197506-02-8

SMILES

O=C1C=C(C2=NN=NN2)OC3=C(/C=C/C4=CC=C(OCCCCC5=CC=CC=C5)C=C4)C=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Kinase Assay
[1]

Equilibrium binding studies are performed at 25°C for 60 min with 0.03-0.5 nM 3H-LTD4 or 40 min with 0.03-0.5 nM 3H-LTC4 and unlabeled homologous or heterologous ligands at the indicated concentrations. A multiligand protocol is followed. Ten micromolar S-decyl-GSH is present only in the case of 3H-LTC4 equilibrium experiments. Time-courses are performed at 25°C with 0.5 nM 3H-LTC4 or 3H-LTD4. Dissociation is induced by adding 1 mM unlabeled leukotriene (homologous dissociation) or 10 μM unlabeled antagonist (heterologous dissociation). In both equilibrium and kinetic studies HLP membranes (0.25 mg per sample), 10 mM HEPES-KOH pH 7.4, 1 mM CaCl2 and 1 mM MgCl2 are added to the incubation mixture to achieve a final volume of 250 mL. All the experiments have been performed under control metabolic conditions. Unbound ligand is separated by rapid vacuum filtration onto glass-fiber GF/C filters soaked in 2.5% polyvinylalchool and the filters are washed twice with 4 mL of HEPES buffer at 4°C. Radioactivity is measured in a liquid scintillation counter.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

LM-1484LM1484LM 1484Leukotriene ReceptorInhibitorinhibitorinhibit

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LM-1484
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HY-101686
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