N3-PEG3-vc-PAB-MMAE
Based on 4 publication(s) in Google Scholar
N3-PEG3-vc-PAB-MMAE is a synthesized agent-linker conjugate for ADC that incorporates the MMAE (a tubulin inhibitor ) and 3-unit PEG linker. N3-PEG3-vc-PAB-MMAE shows potent antitumor activity. N3-PEG3-vc-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 99.07%
- CAS No.: 3046395-46-1
- Formula: C67H109N13O16
- Molecular Weight:1352.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years
* The compound is unstable in solutions, freshly prepared is recommended.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) N3-PEG3-vc-PAB-MMAE
MoreAll Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
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Auristatin |
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of Dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3046395-46-1
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Appearance Solid
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Molecular Weight 1352.66
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Formula C67H109N13O16
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Color White to off-white
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SMILES
O=C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)[C@@H]([C@@H](OC)[C@H](CCC2)N2C(C[C@H]([C@H](N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)C=C3)=O)C)=O)=O)C)[C@H](CC)C)OC)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Publications (4)
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Journal Impact Factor
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Most Recent
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Angew Chem Int Ed Engl
A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein-Protein Conjugates. [Abstract]2020 Jul 27;59(31):12885-12893. PMID: 32342666 -
Bioconjug Chem
High-Throughput Screening of Photo-Cross-Linking Peptide Libraries for Site-Specific Conjugation of IgG. [Abstract]2025 Dec 17;36(12):2655-2664. PMID: 41292069 -
Chembiochem
Efficient Site-Specific Antibody-Drug Conjugation by Engineering a Nature-Derived Recognition Tag for Microbial Transglutaminase. [Abstract]2019 Sep 16;20(18):2411-2419. PMID: 31044494 -
Solvent & Solubility
DMSO : ≥ 100 mg/mL (73.93 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (1.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * The compound is unstable in solutions, freshly prepared is recommended.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (258 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7393 mL | 3.6964 mL | 7.3928 mL | 18.4821 mL |
| 5 mM | 0.1479 mL | 0.7393 mL | 1.4786 mL | 3.6964 mL | |
| 10 mM | 0.0739 mL | 0.3696 mL | 0.7393 mL | 1.8482 mL | |
| 15 mM | 0.0493 mL | 0.2464 mL | 0.4929 mL | 1.2321 mL | |
| 20 mM | 0.0370 mL | 0.1848 mL | 0.3696 mL | 0.9241 mL | |
| 25 mM | 0.0296 mL | 0.1479 mL | 0.2957 mL | 0.7393 mL | |
| 30 mM | 0.0246 mL | 0.1232 mL | 0.2464 mL | 0.6161 mL | |
| 40 mM | 0.0185 mL | 0.0924 mL | 0.1848 mL | 0.4621 mL | |
| 50 mM | 0.0148 mL | 0.0739 mL | 0.1479 mL | 0.3696 mL | |
| 60 mM | 0.0123 mL | 0.0616 mL | 0.1232 mL | 0.3080 mL |
N3-PEG3-vc-PAB-MMAE Related Classifications
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