1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. N3-PEG3-vc-PAB-MMAE

N3-PEG3-vc-PAB-MMAE 

Cat. No.: HY-100874 Purity: 98.79%
Handling Instructions

N3-PEG3-vc-PAB-MMAE is a synthesized drug-linker conjugate for ADC that incorporates the MMAE (a tubulin inhibitor ) and 3-unit PEG linker. N3-PEG3-vc-PAB-MMAE shows potent antitumor activity.

For research use only. We do not sell to patients.

N3-PEG3-vc-PAB-MMAE Chemical Structure

N3-PEG3-vc-PAB-MMAE Chemical Structure

Size Price Stock Quantity
1 mg USD 420 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1620 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

N3-PEG3-vc-PAB-MMAE is a synthesized drug-linker conjugate for ADC that incorporates the MMAE (a tubulin inhibitor ) and 3-unit PEG linker. N3-PEG3-vc-PAB-MMAE shows potent antitumor activity.

IC50 & Target

Auristatin

 

In Vitro

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of Dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1352.66

Formula

C₆₇H₁₀₉N₁₃O₁₆

SMILES

CC[[email protected]](C)[[email protected]@H]([[email protected]@H](CC(N1[[email protected]@H](CCC1)[[email protected]@H]([[email protected]@H](C)C(N[[email protected]](C)[[email protected]@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([[email protected]](C(C)C)NC([[email protected]](C(C)C)N(C(OCC3=CC=C(NC([[email protected]](CCCNC(N)=O)NC([[email protected]](C(C)C)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)C=C3)=O)C)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

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Keywords:

N3-PEG3-vc-PAB-MMAEDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Product Name:
N3-PEG3-vc-PAB-MMAE
Cat. No.:
HY-100874
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