Steroids

25(R)-3β,17α-Dihydroxy-5α-spirostan-6-one 3-O-α-D-rhamnopyranosyl-(1→2)-β-D-glucopyranoside is a compound that can be isolated from Lilium brownii var. viridulum.

k-Strophanthoside is a cardiac glycoside compound that can be isolated from the seeds of Strophanthus kombe.

Ophiopojaponin A is a steroidal glycoside that can be isolated from Polygonatum glaberrimum.

Ponasteroside A is a phytoecdysteroid isolated from the rhizomes of Brainea insignis.

Marsdenoside A (compound 7) is a Marsdenoside isolated from Alocasia genus. Marsdenoside A has a weak growth inhibitory effect on two tumor cell lines, MGC-803 and HT-29, with IC₅₀ >50 μg/mL.

Marstenacisside F1 (compound 1) is a polyoxypregnanoside with anti-inflammatory activity isolated from Marsdenia tenacissima. Marstenacisside F1 inhibits lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells and is a derivative of Tenacigenin B.

3-epi-Digitoxigenin is a triterpene isolated from the leaves and stems of Plumeria frangipani.

11α-O-Tigloyl-12β-O-acetyltenacigenin B is an ester derivative of Tenacigenin B (HY-N1168), which is isolated from Garcinia cambogia (MTC). Tenacigenin B modulates the antitumor effects of Aurora-A in lymphoma.

6β-Hydroxystigmasta-4,22-dien-3-one is a steroid that can be isolated from Hedychium coronarium.

Progenin III palmitate is a steroid glycoside ester isolated from Dioscorea cayenensis rhizomes.

Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively.

Condurango glycoside A0 is a pregnane ester glycoside that can be isolated from Marsdema cundurango.

3β-(Acetyloxy)stigmast-5-en-7-one has anti-complement activity.

Uzarin is a steroid glycoside. Uzarin does not inhibit cell proliferation or induce apoptosis .

Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits Na+/K+-ATPase activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB.

Rubrosterone is a metabolite of insect metamorphosing substances, that can be isolated from Achyranthes rubrofuca and A. fmaiei (Amaranthaceae).

FF-MAS is a potent meiotic maturation agonist. FF-MAS promotes meiotic maturation and preimplantation development of mouse oocytes maturing in vitro. FF-MAS promotes the completion of meiotic maturation to metaphase II (MII) and improves competence to complete the 2-cell stage to blastocyst transition.

6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties.

Anemarrhenasaponin Ia is a steroidal saponin that can be isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Anemarrhenasaponin Ia inhibits platelet aggregation. Anemarrhenasaponin Ia induces mild concentration-dependent hemolysis. Anemarrhenasaponin Ia inhibits fMLP- and AA-induced superoxide anion production, while enhancing PMA-induced superoxide anion production. Anemarrhenasaponin Ia can be used in studies related to thrombosis.

Ophiopojaponin C is a naturally occurring C₂₉ steroidal glycoside isolated from the tubers of O. japonicas.