1. Peptides

Pressinoic Acid 

Cat. No.: HY-P1487
Handling Instructions

Pressinoic Acid is a synthetic hexapeptide with potent corticotrophin-releasing activity. Pressinoic Acid is also an oxytocin inhibitor; it induces maternal behavior.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Pressinoic Acid Chemical Structure

Pressinoic Acid Chemical Structure

CAS No. : 35748-51-7

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Pressinoic Acid is a synthetic hexapeptide with potent corticotrophin-releasing activity. Pressinoic Acid is also an oxytocin inhibitor; it induces maternal behavior.

IC50 & Target

Oxytocin[1]

In Vitro

Pressinoic acid, a synthetic hexapeptide that corresponds to the ring of vasopressin, exhibits corticotrophin-releasing activity in vitro in doses of 3 and 30 ng/mL[1].

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
Cell Assay
[1]

Single halved pituitary glands of female CFE rats weighing 100 to 150 g are preincubated for two hours in Krebs-Ringer-bicarbonate-glucose (2%) medium under 5% CO2 in O2, and then for one hour periods each with 300 ng. lysine vasopressin and the sample of vasopressin ring peptide Pressinoic Acid. The incubations are separated by a one hour ish period. The media from the pituitary incubations are added to rat adrenal quarters superfused for estimation of the steroidogenic response to the corticotrophin released. The steroidogenie effect of the unstimulated release of corticotrophin by the pituitary tissue and the possible steroidogenic effect of the peptide directly on the adrenal tissue are measured together by adding the peptide to the media from pituitary tissue incubated without peptide for one hour[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

774.86

Formula

C₃₃H₄₂N₈O₁₀S₂

CAS No.

35748-51-7

Sequence

Cys-Tyr-Phe-Gln-Asn-Cys (Disulfide bridge: Cys1-Cys6)

Sequence Shortening

CYFQNC (Disulfide bridge: Cys1-Cys6)

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
Pressinoic Acid
Cat. No.:
HY-P1487
Quantity:

Pressinoic Acid

Cat. No.: HY-P1487