Infection

Resorantel (Standard) is the analytical standard of Resorantel. This product is intended for research and analytical applications. Resorantel is an anthelmintic. Resorantel is used in the research of paramphistomiasis in cattle and sheep and has also been used for the research of G. aegypticus.

Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice^[1][2].

Antibacterial agent 158 (compound 6c), a Micrococcin analogue, and is effective against impetigo and C. difficile infection (CDI).

Tur1A is an antimicrobial peptide derived from bottlenose dolphins Tursiops truncates. Tur1A inhibits bacterial protein synthesis by binding to ribosomes and blocking the transition from the initiation stage to the extension stage.

HCV NS5B polymerase-IN-3 (Compound 30a) is an inhibitor of the HCV NS5B polymerase. HCV NS5B polymerase-IN-3 exhibits anti-HCV activity in the Huh7 replicon cell line with an EC₅₀ of 0.23 μM and shows no obvious cytotoxicity. HCV NS5B polymerase-IN-3 can be used in research related to the hepatitis C virus.

Pap12-6 is a 12-mer peptide derived from the antimicrobial peptide Papiliocin of yellow butterfly larva. Pap12-6 kills bacteria by penetrating and disrupting their membranes, exhibiting strong antibacterial activity. Pap12-6 exerts its anti-inflammatory effects through the TLR4-mediated NF-κB signaling pathway.

Uncaric acid (6β,19α-Dihydroxyursolic acid) (compound 6) is a triterpene that can be found in Eriobotrya japonica. Uncaric acid shows anti HIV-1, HRV 1B, SNV activity.

Dextran sulfate, high sulfate (MW 5000) is a type of dextran sulfate with a high degree of sulfation. Dextran sulfate sodium can be used to induce ulcerative colitis models, and the greater the total number of sulfur atoms, the stronger the induced toxic effect. Dextran sulfate has certain antibacterial activity, and can form the ionic cross-linking core of nanoparticles together with chitosan, serving as a highly efficient dressing material to accelerate wound healing.

SARS-CoV-2 3CLpro-IN-40 is a SARS-CoV-2 3CL^pro inhibitor with an IC₅₀ of 2.041 μM. SARS-CoV-2 3CLpro-IN-40 reduces the expression level of viral nucleocapsid protein and the expression levels of proinflammatory cytokines (IL-6, TNF-α and IFN-β). SARS-CoV-2 3CLpro-IN-40 decreases the RNA level of infectious bronchitis virus. SARS-CoV-2 3CLpro-IN-40 inhibits SARS-CoV-2 infection. SARS-CoV-2 3CLpro-IN-40 reduces the replication level of HCoV-OC43. SARS-CoV-2 3CLpro-IN-40 is applicable to research related to coronavirus infection.

Patchouli alcohol (Standard) is the analytical standard of Patchouli alcohol. This product is intended for research and analytical applications. Patchouli alcohol is a natural tricyclic sesquiterpene, exhibits anti-Helicobacter pylori, anti-inflammatory and antioxidant properties.

Oxaquin (MCB-3837) is a injectable proagent that is rapidly converted to the active substance MCB3681 in vivo following intravenous (i.v.) administration, active against Gram-positive bacterial species. Oxaquin (MCB-3837) itself has no antimicrobial effects.

Antibacterial agent 244 is an orally active compound with broad-spectrum antibacterial activity, primarily targeting Gram-positive bacteria, with a MIC value of 1–4 μg/mL and low hemolytic toxicity (HC₅₀ of 111.6 μg/mL). Antibacterial agent 244 disrupts bacterial transmembrane potential, increases membrane permeability, leading to leakage of cellular contents such as DNA and proteins, ultimately causing bacterial death. Antibacterial agent 244 can be used in research related to Gram-positive bacterial infections.

Dezaguanine is a purine analog. Dezaguanine exhibits antitumor activity in leukemia and breast cancer cells. Dezaguanine can be used in cancer-related research.

Xeruborbactam methoxy acetoxy methy ester is a boronic acid β-lactamase inhibitor, exacted from WO2018005662A1, compound 43.

Secnidazole (RP-14539) hemihydrate is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole hemihydrate, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole hemihydrate has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole hemihydrate can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis.

BMAP-27 acetate is a cationic amphipathic α-helical antimicrobial peptide with anticancer activity. BMAP-27 acetate disrupts the integrity and permeability of cell membranes, leading to the leakage of intracellular DNA, proteins and alkaline phosphatase. BMAP-27 acetate increases intracellular ROS levels and reduces plasma endotoxin and TNF-α concentrations. BMAP-27 acetate can be used in studies related to Salmonella infection, breast cancer, lung cancer and obstructive jaundice.

Catalpanp-1 is a potent anti-microbial agent. Catalpanp-1 has strong antimicrobial effect on yeast, bacteria, fungi and the like.

Trigonelline-d₃-1 chloride (Trigonelline-d₃-1 hydrochloride) is the deuterium labeled Trigonelline chloride (HY-N0415). Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

NPI52 (Compound E1) is a foot-and-mouth disease virus 3C protease (FMDV 3Cpro) inhibitor, with IC₅₀ values of 0.05 and 0.11 µM in FRET and cell-based assay, respectively.

Fosmanogepix TFA (APX001 TFA) is an orally active APX001A (HY-18233) prodrug and antifungal agent. Fosmanogepix TFA is effective against Cryptococcus neoformans, Fluconazole (HY-B0101)-resistant C. auris. Fosmanogepix TFA is effective in the treatment of invasive pulmonary aspergillosis and pulmonary murine mucormycosis.