2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N1372AR
    Fangchinoline (Standard) 436-77-1 98%
    Fangchinoline (Standard) is the analytical standard of Fangchinoline. This product is intended for research and analytical applications. Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing. Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK. Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer.
    Fangchinoline (Standard)
  • HY-N1428AR
    Citric acid monohydrate (Standard) 5949-29-1 98%
    Citric acid monohydrate (Standard) is the analytical standard of Citric acid monohydrate (HY-N1428A). This product is intended for research and analytical applications. Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
    Citric acid monohydrate (Standard)
  • HY-N1428S2
    Citric acid-13C2 224054-26-6 98%
    Citric acid-13C2 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
    Citric acid-13C2
  • HY-N144101
    SARS-CoV MPro-IN-2 81418-42-0 98%
    SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 72.07 nM. The main protease (Mpro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in agent discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19.
    SARS-CoV MPro-IN-2
  • HY-N1480S1
    (-)-Fucose-13C-1 83379-37-7 98%
    (-)-Fucose-13C-1 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-1
  • HY-N1480S2
    (-)-Fucose-13C-2 478518-50-2 98%
    (-)-Fucose-13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-2
  • HY-N1480S3
    (-)-Fucose-13C-3 478518-51-3 98%
    (-)-Fucose-13C-3 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-13C-3
  • HY-N1500S1
    Pulegone-d8 98%
    Pulegone-d8 is deuterated labeled Pulegone (HY-N1500). Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.
    Pulegone-d8
  • HY-N15194A
    Inostamycin A sodium 98%
    Inostamycin A sodium is an inhibitor of cytidine-5'-diphosphate-1,2-diacyl-sn-glycerol (CDP-DG):inositol transferase. Inostamycin A sodium reduces phosphatidylinositol turnover, and inhibits cell proliferation and transformation. Inostamycin A sodium inhibits cancer cell proliferation, induces apoptosis, and prevents tumor recurrence. Inostamycin A sodium exhibits antibacterial activity. Inostamycin A sodium is applicable to research related to infection and cancer.
    Inostamycin A sodium
  • HY-N15534A
    5α,6β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-7E-megastigmen-9-one 98%
    5α,6β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-7E-megastigmen-9-one (Compound 18) is a megastigmane glucoside isomer. 5α,6β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-7E-megastigmen-9-one can be isolated from the Piper genus and Piperaceae family.
    5α,6β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-7E-megastigmen-9-one
  • HY-N1584BR
    Halofuginone hydrochloride (Standard) 1217623-74-9
    Halofuginone (hydrochloride) (Standard) is the analytical standard of Halofuginone (hydrochloride). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[4].
    Halofuginone hydrochloride (Standard)
  • HY-N16437A
    Panowamycin B 1375224-56-8
    Panowamycin B is an isochroman compound that can be produced by Streptomyces sp. K07-0010. Panowamycin B exhibits antitrypanosomal activity against the Trypanosoma brucei brucei GUTat 3.1 strain (IC50: 3.30 μg/mL). Panowamycin B shows weak cytotoxicity towards human fetal lung fibroblast MRC-5 cells (IC50: 13 μg/mL). Panowamycin B can be used for research in the field of antitrypanosomal studies.
    Panowamycin B
  • HY-N18117A
    23-Hydroxyohchininolide 1429747-10-3 98%
    23-Hydroxyohchininolide is a limonoid found in the leaves of Melia azedarach L.. 23-Hydroxyohchininolide inhibits LPS (HY-D1056)-induced NO production and exerts cytotoxic activity against human leukemia and stomach cancer cells. 23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen activation. 23-Hydroxyohchininolide can be used for the research of cancer, infection and inflammatory disease.
    23-Hydroxyohchininolide
  • HY-N1952S1
    Isoeugenol-13C 98%
    Isoeugenol-13C (Iso-Eugenol-13C) is the 13C-labeled Isoeugenol (HY-N1952). Isoeugenol is an essential oil constituent of nutmeg, clove, and cinnamon. Isoeugenol inhibits growth of Escherichia coli and Listeria innocua with MICs of 0.6 mg/mL and 1 mg/mL, respectively
    Isoeugenol-13C
  • HY-N2026AR
    Propylparaben sodium (Standard) 35285-69-9
    Propylparaben (sodium) (Standard) is the analytical standard of Propylparaben (sodium). This product is intended for research and analytical applications. Propylparaben sodium (Propyl parahydroxybenzoate) is an antimicrobial preservative which can be produced naturally by plants and bacteria. Propylparaben sodium is prevalently used in cosmetics, pharmaceuticals, and foods. Propylparaben sodium disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways. Propylparaben sodium also decreases sperm number and motile activity in rats.
    Propylparaben sodium (Standard)
  • HY-N2041S5
    Myristic acid-d1 358730-97-9 98%
    Myristic acid-d is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.
    Myristic acid-d1
  • HY-N6717S1
    Tentoxin-13C22
    Tentoxin-13C22 is the 13C-labeled Tentoxin (HY-N6717). Tentoxin is a cyclic tetrapeptide isolated from Alternaria tenuis, acts as a herbicide, causes seedling chlorosis, inhibits cyclic photophosphorylation and functions as an energy transfer inhibitor.
    Tentoxin-13C22
  • HY-N6726S1
    Fumonisin B3-13C34-1 1217494-88-6 98%
    Fumonisin B3-13C34-1 is the isotopic internal standard of Fumonisin B3 (HY-N6726). Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma.
    Fumonisin B3-13C34-1
  • HY-N6746S1
    Citrinin-13C13 98%
    Citrinin-13C13 (NSC 186-13C13) is the 13C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity.
    Citrinin-13C13
  • HY-N7071AR
    Maduramicin ammonium (Standard) 84878-61-5
    Maduramicin (ammonium) (Standard) is the analytical standard of Maduramicin (ammonium). This product is intended for research and analytical applications. Maduramicin ammonium (Maduramycin ammonium) is isolated from the actinomycete Actinomadura rubra. Maduramicin ammonium (Maduramycin ammonium) is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection. Maduramicin ammonium (Maduramycin ammonium) induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways.
    Maduramicin ammonium (Standard)
Cat. No. Product Name / Synonyms Application Reactivity