Infection

R-95845 is a non-nucleoside HIV-1 reverse transcriptase (RT) inhibitor. R-95845 is specific to HIV-1 RT and acts as a functionally non-competitive inhibitor with respect to nucleotide incorporation. R-95845 binds to the non-nucleoside inhibitor binding pocket of HIV-1 RT in a butterfly-like conformation, forms hydrogen bonds with Tyr 188 and Val 189, and engages in hydrophobic interactions with surrounding residues. R-95845 can be used in studies related to HIV-1 infection and acquired immunodeficiency syndrome.

4′-Hydroxy-2′-methylacetophenone (Standard) is the analytical standard of 4′-Hydroxy-2′-methylacetophenone (HY-W010254). This product is intended for research and analytical applications. 4′-Hydroxy-2′-methylacetophenone, an aroma compound of red wines, is isolated from cv. Bobal grape variety. 4′-Hydroxy-2′-methylacetophenone has ciliate toxicity. 4′-Hydroxy-2′-methylacetophenone inhibits the growth of T. pyriformis, with an IC50 of 0.65 mM.

1-Hexacosanol (Standard) is the analytical standard of 1-Hexacosanol. This product is intended for research and analytical applications. 1-Hexacosanol can be used as an inhibitor of acetylcholinesterase (AChE). 1-Hexacosanol has larvicidal activity and can inhibit the acetylcholinesterase activity of Culex quinquefasciatus, Aedes aegypti and Chironomus riparius, exerting neurotoxic effects.

6-Aminopenicillanic acid (Standard) is the analytical standard of 6-Aminopenicillanic acid. This product is intended for research and analytical applications. 6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses.

HIV-1 inhibitor-79 (Compound 3k) is an HIV inhibitor that exhibits significant inhibitory activity against HIV-1 and its common mutant strains (with IC₅₀ values of 1.9, 1.9, 8.7, and 11 nM against HIV-1, K103, L100I, and E138K, respectively), and has low cytotoxicity and a high selectivity index (CC₅₀ = 21.95 μM, SI = 11478). Additionally, HIV-1 inhibitor-79 also shows antiviral activity against HIV-2, with an EC₅₀ value of 6.14 μM, and significantly inhibits the activity of HIV-1 reverse transcriptase (IC₅₀ = 25 nM).

Sesquicillin A is an insecticidal antibiotic, a fungal metabolite isolated from white plantain. Sesquicillin A inhibits the growth of A. salina brine shrimp with the MIC value of 6.25 µg/mL.

Carbenicillin (disodium) (Standard) is the analytical standard of Carbenicillin (disodium). This product is intended for research and analytical applications. Carbenicillin disodium (Sodium carbenicillin) is a broad-spectrum semi-synthetic penicillin antibiotic for gram-negative bacteria. Carbenicillin disodium can interfere the cell wall synthesis while displaying low toxicity to plant tissue.

Succinate dehydrogenase-IN-7 (Compound 2f) is a Succinate dehydrogenase inhibitor (IC₅₀ = 2.51 μM). Succinate dehydrogenase-IN-7 has fungicidal activity.

SPK-843 is an antifungal agent. SPK-843 shows inhibitory activity against A. fumigatus MF-13, A. flavus TIMM 0057, and A. niger TIMM 2814 with MICs of 0.5 μg/mL, 0.25 μg/mL, and 0.0625 μg/mL, respectively. SPK-843 exhibits dose-dependent efficacy in murine models of pulmonary aspergillosis. SPK-843 can be used for the research of related fungal infections.

Demethylblasticidin S is an antifungal antibiotic that can be synthesized by Streptomyces griseochromogenes.

NAI-802 is a new lantibiotic. NAI-802 can be produced by Actinoplanes sp. NAI-802 shows a significant activity against Gram-positive anaerobic bacteria, such as Clostridium difficile, C. butyricum, C. perfringens and Peptostreptococcus asaccharolyticus with MIC ranges of 0.25-2 μg/mL.

MeV-IN-1 (OX-1) is a specific entry inhibitor targeting measles virus (MeV), with an IC₅₀ value of 100 μM. MeV-IN-1 exhibits inhibitory activity against live MeV-Edm virus. MeV-IN-1 effectively suppresses the formation of infection foci. MeV-IN-1 can be used in studies related to measles virus infection.

Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (M^pro), which can be used in the research of anti-novel coronavirus drugs.

4-Methoxy-p-toluquinone is a quinone antibiotic found in the fungus Coprinus siniilis, Lentinus degener. 4-Methoxy-p-toluquinone has anti-bacterial, mycobacterial and fungal effects, but is weak against Gram-negative bacteria. The serum will inactivate it.

5-Phenyllevulinic acid (4-Oxo-5-phenylpentanoic acid) is an endogenous fungal metabolite with inhibitory activity against the bacterium B. megaterium, the plant pathogenic fungus S. tritici, and the alga C. fusca. 5-Phenyllevulinic acid is also an intermediate in the synthesis of σ receptor ligands. 5-Phenyllevulinic acid holds potential for research in the field of anti-infection studies .

nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism.

U18666A (Standard) is the analytical standard of U18666A (HY-107433). This product is intended for research and analytical applications. U18666A, an intra-cellular cholesterol transport inhibitor, inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.

Schirubridilactone D is a HIV-1 inhibitor with an EC₅₀ of 80.8 µg/mL. Schirubridilactone D is a nortriterpenoid isolated from the leaves and stems of Schisandra rubriflora. Schirubridilactone D inhibits HIV-1 replication and blocks HIV-1-induced cytopathic effects. Schirubridilactone D is applicable to research related to HIV-1 infection.

GSK369796 is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC₅₀ of 7.5 μM.

ddATP (lithium) (2',3'-Dideoxyadenosine 5'-triphosphate (lithium)) is an active metabolite of 2',3'-dideoxyinosine and a DNA polymerase chain elongation inhibitor. ddATP (lithium) is used in Sanger DNA sequencing and in research related to viral infection^{[1][2][3][4][5]}.