Schirubridilactone D
Schirubridilactone D is a HIV-1 inhibitor with an EC50 of 80.8 µg/mL. Schirubridilactone D is a nortriterpenoid isolated from the leaves and stems of Schisandra rubriflora. Schirubridilactone D inhibits HIV-1 replication and blocks HIV-1-induced cytopathic effects. Schirubridilactone D is applicable to research related to HIV-1 infection.
For research use only. We do not sell to patients.
- CAS No.: 1210051-95-8
- Formula: C29H34O10
- Molecular Weight:542.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 80.8 μM (EC50) |
Schirubridilactone D (compound 4) inhibits HIV-1-induced cytopathic effects in C8166 cells with an EC50 of 80.8 µg/mL and a selectivity index of 2.2[1].
Schirubridilactone D (compound 257) inhibits HIV-1 replication in infected C8166 cells with an EC50 of 80.8 μg/mL and a selectivity index of 2.2[2].
Schirubridilactone D does not exhibit obvious cytotoxic activity against K562 or HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1210051-95-8
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Molecular Weight 542.57
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Formula C29H34O10
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SMILES
O=C1[C@@]23[C@]4(C[C@@]56[C@@](C(C)(O[C@]5([H])CC(O6)=O)C)([H])C[C@]2([H])O3)O[C@@]17[C@]8([H])[C@](CC4)(C([C@H]([C@]8([H])[C@]9([H])[C@]([C@@H](C(O9)=O)C)([H])O7)C)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xiao WL, et al. Chemical constituents from the leaves and stems of Schisandra rubriflora. Journal of natural products. 2010 Feb 26;73(2):221-5. [Content Brief]
[2]. Wu HF, et al. Recent advances in natural anti-HIV triterpenoids and analogs. Medicinal research reviews. 2020 Nov;40(6):2339-2385. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Schirubridilactone D Related Classifications
HY-N19901 Related Classifications
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