Chemical constituents from the leaves and stems of Schisandra rubriflora

  • J Nat Prod. 2010 Feb 26;73(2):221-5. doi: 10.1021/np900849y.
Wei-Lie Xiao  1 ,  Shi-Ying Yang ,  Liu-Meng Yang ,  Guang-Yu Yang ,  Rui-Rui Wang ,  Hai-Bo Zhang ,  Wei Zhao ,  Jian-Xin Pu ,  Yang Lu ,  Yong-Tang Zheng ,  Han-Dong Sun
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
PMID: 20146529 DOI: 10.1021/np900849y
Abstract

Six new nortriterpenoids, schirubridilactones A-F (1-6), as well as 14 known compounds, were isolated from the leaves and stems of Schisandra rubriflora. The structures of 1-6 were elucidated on the basis of spectroscopic methods including HSQC, HMBC, (1)H-(1)H COSY, and ROESY NMR experiments. The relative stereochemistry of 1 was confirmed through single-crystal X-ray analysis. In addition, compounds 1-6 showed anti-HIV-1 activity with EC(50) values in the range 14.3-80.8 microg/mL and selectivity indices in the range 2.2-9.0.