2. Anti-infection
  3. Measles Virus
  4. MeV-IN-1

MeV-IN-1 (OX-1) is a specific entry inhibitor targeting measles virus (MeV), with an IC50 value of 100 μM. MeV-IN-1 exhibits inhibitory activity against live MeV-Edm virus. MeV-IN-1 effectively suppresses the formation of infection foci. MeV-IN-1 can be used in studies related to measles virus infection.

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MeV-IN-1

MeV-IN-1 Chemical Structure

CAS No. : 313527-44-5

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MeV-IN-1 Related Antibodies

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Description

MeV-IN-1 (OX-1) is a specific entry inhibitor targeting measles virus (MeV), with an IC50 value of 100 μM. MeV-IN-1 exhibits inhibitory activity against live MeV-Edm virus. MeV-IN-1 effectively suppresses the formation of infection foci. MeV-IN-1 can be used in studies related to measles virus infection[1].

Cellular Effect
Cell Line Type Value Description References
Vero CC50
>600 μM
Compound: 1a
Cytotoxicity against Vero-CD150w cells
Cytotoxicity against Vero-CD150w cells
[PMID: 16913698]
Vero EC50
>8 μM
Compound: 24, OX-1
Inhibition of Nipah virus glycoprotein G/F-mediated cell-cell fusion expressed in african green monkey Vero cells after 24 hrs relative to untreated control
Inhibition of Nipah virus glycoprotein G/F-mediated cell-cell fusion expressed in african green monkey Vero cells after 24 hrs relative to untreated control
[PMID: 19499921]
Vero EC50
0.4 μM
Compound: 24, OX-1
Inhibition of Measles virus hemagglutininin/F-mediated cell-cell fusion expressed in african green monkey Vero cells after 24 hrs relative to untreated control
Inhibition of Measles virus hemagglutininin/F-mediated cell-cell fusion expressed in african green monkey Vero cells after 24 hrs relative to untreated control
[PMID: 19499921]
Vero EC50
8 μM
Compound: 24, OX-1
Cytotoxicity against african green monkey Vero cells after 16 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells after 16 hrs by MTT assay
[PMID: 19499921]
In Vitro

MeV-IN-1 (20-30 h) specifically inhibits the replication of live MV-Edm in Vero/HeLa cells, with an IC50 of approximately 55 μM, and induces only negligible cytotoxicity even at concentrations as high as 600 μM[1].
MeV-IN-1 (30 h) inhibits measles virus glycoprotein-mediated membrane fusion in transfected cells, with an IC50 of approximately 100 μM[1].
MeV-IN-1 (300 μM; 1 h-30 h) does not interfere with the adhesion of MV-Edm to Vero/HeLa cells, but inhibits the post-adhesion entry process of the virus by targeting membrane fusion[1].
MeV-IN-1 (300 μM; 30 min) inhibits membrane lipid fusion induced by measles virus (MV) glycoproteins in transfected cells, but has no effect on lipid fusion mediated by SV5[1].
MeV-IN-1 (0-600 μM) exhibits mutation-specific activity against measles virus (MV) recombinants in Vero/HeLa cells, with enhanced potency against MV-FV94M, MV-FV94L and MV-FV94I, reduced potency against MV-FV94A, and high resistance observed for MV-FV94G, which confirms that the cavity of the F protein is its target site[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MeV-IN-1 Related Antibodies
Molecular Weight

224.26

Formula

C14H12N2O
CAS No.
SMILES

NC1=CC=C(OC(CC2=CC=CC=C2)=N3)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MeV-IN-1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MeV-IN-1313527-44-5OX-1OX1OX 1Measles VirusMeVGram-positive bacteriameasles virusPseudomonas aeruginosa ATCC 10145Gram-negative bacteriameasles virus fusion proteinCandida albicansBacillus subtilis ATCC 6633Vero/HeLa cellsStaphylococcus aureus ATCC 25923Escherichia coli ATCC 23556Inhibitorinhibitorinhibit

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