GSK369796

Cat. No.: HY-12082: Data Sheet Handling Instructions
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GSK369796 is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC₅₀ of 7.5 μM.

For research use only. We do not sell to patients.

GSK369796 Chemical Structure

CAS No. : 459133-38-1

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of GSK369796:

GSK369796 Dihydrochloride

Other Forms of GSK369796:

GSK369796 Dihydrochloride In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

GSK369796 is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC₅₀ of 7.5 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BHK-21	CC₅₀	98.01 μM Compound: 42; GSK369796	Cytotoxicity against BHK21 cells after 24 to 48 hrs by CCK8 assay Cytotoxicity against BHK21 cells after 24 to 48 hrs by CCK8 assay	[PMID: 31549836]
Vero	EC₅₀	2.57 μM Compound: 42; GSK369796	Antiviral activity against Zika virus MR766 infected in African green monkey Vero cells by plaque assay Antiviral activity against Zika virus MR766 infected in African green monkey Vero cells by plaque assay	[PMID: 31549836]
Vero C1008	EC₅₀	1.2 μM Compound: N-tert-Butylisoquine	Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs Determination of antiviral efficacy in high-content imaging assay in Vero E6 cells infected with SARS-CoV-2 (USA-WA1/2020 isolate) at MOI 0.75 after 24 hrs	10.1101/2020.04.16.044016

Clinical Trial

Molecular Weight

355.86

Formula

C₂₀H₂₂ClN₃O

CAS No.

459133-38-1

SMILES

OC1=CC(NC2=CC=NC3=CC(Cl)=CC=C23)=CC=C1CNC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. O'Neill PM, et al. Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. J Med Chem. 2009 Mar 12;52(5):1408-15. [Content Brief]

GSK369796 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK369796459133-38-1GSK 369796GSK-369796Potassium ChannelParasiteKcsAantimalarialhERGInhibitorinhibitorinhibit

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