Infection

Schirubridilactone D is a HIV-1 inhibitor with an EC₅₀ of 80.8 µg/mL. Schirubridilactone D is a nortriterpenoid isolated from the leaves and stems of Schisandra rubriflora. Schirubridilactone D inhibits HIV-1 replication and blocks HIV-1-induced cytopathic effects. Schirubridilactone D is applicable to research related to HIV-1 infection.

Propiconazole-d₇ is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC₅₀s=0.04 and >200 μM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).

Maridomycin V is a macrolide antibiotic. Maridomycin Vhas the activity against Gram-positive bacteria and mycoplasma. Maridomycin V has the effect of protecting Gram-positive bacterial infection mice.

QST4 has antitubercular activity, with the MIC value of 6.25 μM in Mycobacterium tuberculosis H37Rv.

Arohynapene A is an anticoccidial compound that inhibits the growth of Eimeria tenella.

Amidomycin is an antibiotic active primarily against yeast.

Daumone is a natural product secreted by Caenorhabditis elegans. Daumone can be used for aging and obesity research and the development of anti-nematode drugs.

PD-L1/LpxC-IN-1 (Conpound 12b) is the inhibitor for PD-L1 and LpxC with IC₅₀ of 5.2 μM and 0.081 μM. PD-L1/LpxC-IN-1 inhibits the biosynthesis of bacterial lipopolysaccharide, causes the lysis and death of bacterial cells. PD-L1/LpxC-IN-1 inhibits Gram-negative bacteria, MIC for K. pneumoniae ATCC 13883, E. coli ATCC 8739, S. typhimurium ATCC 14028 and P. aeruginosa ATCC 9027 is 0.25-0.5 μg/mL. PD-L1/LpxC-IN-1 downregulates the expression of inflammatory factors IL-2 and IFN-γ, upregulates the expression of CD4+ and CD8+ cells, thereby activating the immune system and inhibiting excessive inflammatory responses. PD-L1/LpxC-IN-1 exhibits antibacterial activity in K. pneumoniae ATCC 13883 infected mouse models.

8''-Hydroxypactamycin is an antibiotic found in Streptomyces SIPI-A-3-0121.

Avermectin B1a monosaccharide is a macrolide anthelmintic that can inhibit Caenorhabditis elegans.

ATPase-IN-6 is a H⁺/K⁺- ATPase inhibitor and a prazole derivative. ATPase-IN-6 has significant antiviral activity against multiple viruses, such as HIV-1 and SARS-COV2. ATPase-IN-6 can be used for antiviral infections research.

Quinocycline B, a quinone-containing glycoside antibiotic, demonstrates resistance against Gram-positive bacteria.

Cyclo(L-leucyl-L-valyl) inhibits Aflatoxin production by Aspergillus parasiticus.Cyclo(L-leucyl-L-valyl) inhibits transcription of the Aflatoxin-related genes aflR, hexB, pksL1, and dmtA..

Everninomicin D is an antibiotic that is highly active against Gram-positive bacteria.

Antibiofilm agent-4 (compound 4p) is a LasR inhibitor. Antibiofilm agent-4 shows the best antibiofilm and anti-QS properties.

RCB18350 is an antituberculosis agent that belongs to the class of isoxazole derivatives. RCB18350 has bacteriostatic activity and inhibits the growth of Mycobacterium tuberculosis with an MIC of 1.25 μg/mL. RCB18350 is effective against multidrug-resistant Mycobacterium tuberculosis (MDR-TB) clinical isolates, slow-growing mycobacteria such as Mycobacterium bovis BCG and Mycobacterium avium.

SARS-CoV-2 RdRp-IN-1 (Compound PAP-2) is a potent SARS-CoV-2 RdRp inhibitor, with an EC₅₀ of 1.11 μM. SARS-CoV-2 RdRp-IN-1 can bind directly to SARS-CoV-2 RdRp, fully resistance to the exoribonuclease (ExoN) and exhibit broad spectrum anti-CoV activities.

DprE1-IN-16 is a DprE1 inhibitor against Mycobacterium tuberculosis, with an IC₅₀ value of 11.74 μM. DprE1-IN-16 binds within the catalytic site of DprE1, forming hydrogen bonds, π-cation interactions, π-sulfur interactions and hydrophobic contacts with Lys134, Gly117, Tyr415, Lys418, Cys387 and Val365. DprE1-IN-16 can be used in the research of bacterial and fungal infections as well as tuberculosis.

Milbemycin α12 is an antibiotic and has the effect of killing nematodes and mites.

FK 089 is an antibacterial Agent. FK 089 can be used for the research of infection.