Daumone
Daumone is a natural product secreted by Caenorhabditis elegans. Daumone can be used for aging and obesity research and the development of anti-nematode drugs.
For research use only. We do not sell to patients.
- CAS No.: 690991-47-0
- Formula: C13H24O6
- Molecular Weight:276.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.02 μM
Compound: Daumone
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Growth inhibition of human A549 cells
Growth inhibition of human A549 cells
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[PMID: 28814374] |
| A549 | IC50 |
0.03 μg/mL
Compound: 1
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Anticancer activity against human A549 cells after 72 hrs by sulforhodamine B assay
Anticancer activity against human A549 cells after 72 hrs by sulforhodamine B assay
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[PMID: 19342127] |
| HCT-15 | IC50 |
0.05 μg/mL
Compound: 1
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Anticancer activity against human HCT15 cells after 72 hrs by sulforhodamine B assay
Anticancer activity against human HCT15 cells after 72 hrs by sulforhodamine B assay
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[PMID: 19342127] |
| SK-MEL-2 | IC50 |
0.07 μg/mL
Compound: 1
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Anticancer activity against human SK-MEL-2 cells after 72 hrs by sulforhodamine B assay
Anticancer activity against human SK-MEL-2 cells after 72 hrs by sulforhodamine B assay
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[PMID: 19342127] |
| SK-OV-3 | IC50 |
0.02 μg/mL
Compound: 1
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Anticancer activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
Anticancer activity against human SKOV3 cells after 72 hrs by sulforhodamine B assay
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[PMID: 19342127] |
| XF498 | IC50 |
0.09 μg/mL
Compound: 1
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Anticancer activity against human XF498 cells after 72 hrs by sulforhodamine B assay
Anticancer activity against human XF498 cells after 72 hrs by sulforhodamine B assay
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[PMID: 19342127] |
Chemical Information
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CAS No. 690991-47-0
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Molecular Weight 276.33
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Formula C13H24O6
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SMILES
OC(CCCC[C@@H](C)O[C@H]1[C@@H](C[C@H]([C@@H](O1)C)O)O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Metabolic Diseases
AMP-activated protein kinase, AMPK, is a conserved cellular energy sensor that responds to reduced cellular energy status and coordinates metabolism by increasing ATP-generating catabolic pathways while suppressing ATP-consuming anabolic processes. In metabolic disease research, the AMPK pathway is experimentally relevant because it regulates hepatic lipid synthesis, fatty acid oxidation, glucose production, skeletal-muscle glucose disposal, mTORC1-linked biosynthesis, autophagy, mitochondrial homeostasis, and whole-body energy balance. The central pathway logic is that energy stress, metformin, exercise-like stimulation, or direct AMPK activators increase AMPKα Thr172 phosphorylation and downstream substrate phosphorylation, including ACC and RAPTOR. Phosphorylation of ACC suppresses lipogenesis and supports fatty acid oxidation, whereas phosphorylation of RAPTOR suppresses mTORC1 signaling and links cellular energy status to growth and protein synthesis control. The pathway is linked
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Daumone Related Classifications
HY-142025 Related Classifications
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