Neurological Disease

A1AR antagonist 3 (compound 13) is a selective adenosine 1 (A1) receptor antagonist with K_is of 9.69 nM and 0.529 nM for human A1 and rat A1, respectively. A1AR antagonist 3 can be used for researching neurological diseases.

Nurr1/RXR dual agonist 1 is a dual activator of Nurr1 (EC₅₀ = 2.6 µM) and RXR with Ks of 0.6 and 1.1 µM, respectively. Nurr1/RXR dual agonist 1 exclusively activates the heterodimer response element DR5 by selectively destabilizing the Nurr1 homodimer and stabilizing the Nurr1:RXR heterodimer. Nurr1/RXR dual agonist 1 enhances expression of a specific subset of neuroprotective Nurr1 target genes while avoiding induction of genes associated with potential off-target effects in neuronal cells. Nurr1/RXR dual agonist 1 can be used for neurodegenerative diseases research.

Poneratoxin is the modulator for voltage-gated sodium channel (NaV, EC₅₀ for NaV1.6 and NaV1.7 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals.

Methyl 2-(5-acetyl-2,3-dihydrobenzofuran-2-yl)propenoate can be isolated from roots of Microglossa Pyrifolia. Microglossa Pyrifolia roots has analgesic and hepatic activities.

Levomepromazine-d₆ hydrochloride (Methotrimeprazine-d₆ hydrochloride) is the deuterium labeled Levomepromazine hydrochloride. Levomepromazine (Methotrimeprazine) hydrochloride is an orally active antipsychotic compound and Ca²⁺ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca²⁺ levels. Levomepromazine hydrochloride has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine hydrochloride can induce adaptive ER stress and autophagy. In addition, Levomepromazine hydrochloride has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine hydrochloride can be used in the study psychiatric disorders and relieving nausea and vomiting.

L-Hyoscyamine-d₃-1 (Hyoscyamine-d₃) is the deuterium labeled L-Hyoscyamine (HY-N0471). L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205).

Fructus chebulae extract is an extract of Terminalia chebula Retz. that can be used for ischemia-related injuries.

NEK7 degrader-3 is an orally active and brain-penetrant NEK7 molecular glue degrader with a DC₅₀ of 33.1 nM. NEK7 degrader-3 mediates interaction between NEK7 and E3 ligase cereblon, promoting proteasomal degradation of NEK7 and attenuating NLRP3 inflammasome-mediated inflammatory responses. NEK7 degrader-3 inhibits caspase-1 activity, cytokine release of IL-1β, IL-1α, and IL-18, and pyroptosis-related plasma membrane permeabilization. NEK7 degrader-3 shows antiinflammatory activity in an LPS (HY-D1056)-induced neuroinflammation mouse model. NEK7 degrader-3 can be used for the research of neuroinflammation.

Synuclein gamma, U-¹⁵N is the ¹⁵N-labeled Synuclein gamma.

5-Oxoprolyltryptophan is a model substrate for investigating the increase of serotonin at the cerebral level.

Cy3 labled Tominersen sodium is a Cy3 labled Tominersen sodium.

Davasaicin (KR 25018), Capsaicin (HY-10448) derivative, is an orally active analgesic agent.

ABHD antagonist 2 (Compound 9) is an antagonist for alpha/beta-Hydrolase domain containing 6 (ABHD6), with IC₅₀ <0.001 μM. ABHD antagonist 2 exhibits good binding ability with ABHD6, with IC₅₀ of 0.002 μM.

Zimelidine dihydrochloride (Standard) is the analytical standard of Zimelidine dihydrochloride (HY-110023). This product is intended for research and analytical applications. Zimelidine dihydrochloride is an orally active selective serotonin reuptake inhibitor. Zimelidine dihydrochloride competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine dihydrochloride time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine dihydrochloride strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine dihydrochloride exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine dihydrochloride is used for the study of depressive disorders and analgesic tolerance.

(R)-3C4HPG is an NMDA receptor antagonist.

Rabelomycin is an angucycline antibiotic and inducible nitric oxide synthase (iNOS) inhibitor with an IC₅₀ of 63.9 μM. Rabelomycin can be used in research on bacterial infections, Alzheimer's disease, and Huntington's disease.

Tiropramide-d₅ oxalate (CR 605-d₅ oxalate) is the deuterium labeled Tiropramide oxalate. Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia.

NocII is an orphan neuropeptide which stimulates locomotion in mice.

BMS-181885 is a selective 5-HT₁ receptor agonist and a ligand for 5-HT_1B/_1D receptors. BMS-181885 exhibits anti-migraine activity. BMS-181885 can be used in the research of neurological diseases such as migraine.

BN-82451 dihydrochloride, an orally active and CNS-penetrated antioxidant and a multitargeting neuroprotective agent, exert a significant protection in experimental animal models mimicking aspects of cerebral ischemia, Parkinson disease, Huntington disease, and more particularly amyotrophic lateral sclerosis.