2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Poneratoxin

Poneratoxin is a peptide toxin, which regulates the sodium currents in mammalian, and causes long-lasting pain.

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Poneratoxin Chemical Structure

Poneratoxin Chemical Structure

CAS No. : 137084-94-7

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Poneratoxin Related Antibodies

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Description

Poneratoxin is a peptide toxin, which regulates the sodium currents in mammalian, and causes long-lasting pain[1].

In Vivo

Poneratoxin causes immediate and long-lasting nocifensive behaviours (20 to 600 pmol, intraplantar injection, single dose) in C57BL/6 J mice model, and leads to paralysis with PD50 (1 h) of 74.3 nmol/g in blowflies model (0-100 nmol/g, ip, single dose)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J mice model[1]
Dosage: 20 to 600 pmol
Administration: intraplantar injection, single dose
Result: Caused spontaneous nocifensive behaviours.
Animal Model: blowflies model[1]
Dosage: 0-100 nmol/g
Administration: Ip, single dose
Result: Caused paralysis.
Molecular Weight

2756.35

Formula

C129H215N33O31S
CAS No.
Sequence

Phe-Leu-Pro-Leu-Leu-Ile-Leu-Gly-Ser-Leu-Leu-Met-Thr-Pro-Pro-Val-Ile-Gln-Ala-Ile-His-Asp-Ala-Gln-Arg-NH2
Sequence Shortening

FLPLLILGSLLMTPPVIQAIHDAQR-NH2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Poneratoxin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Poneratoxin137084-94-7Sodium ChannelNa channelsNa+ channelsParaponera clavataC57BL/6?J miceInhibitorinhibitorinhibit

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HY-P10234
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