Neurological Disease

5-HT7R antagonist 4 (Compound 4) is a potent 5-HT₇ receptor antagonist (K_i=2.6 nM) with low binding affinity for the 5-HT₁A receptor (K_i= 476 nM). 5-HT7R antagonist 4 is promising for research of neurological diseases.

ε-Rhodomycinone is a bacterial metabolite found in S. griseoruber. It is a precursor to Rhodomycin D, which is an intermediate in the bioconversion of ε-rhodomycinone to Daunorubicin (HY-13062) and Doxorubicin (HY-15142R).

MMB-ICA is a metabolite of MMB-CHMICA.

Dicyclomine (hydrochloride) (Standard) is the analytical standard of Dicyclomine (hydrochloride). This product is intended for research and analytical applications. Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo.

SMW139 is a selective allosteric antagonist of P2X₇ receptor, with a K_i value of 32 nM for human P2X₇R. The half-life of SMW139 in rat liver microsomes is 47 minutes. SMW139 can be used for inflammation, Alzheimer’s disease, multiple sclerosis study.

(Rac)-Lanicemine (Standard) is the analytical standard of (Rac)-Lanicemine. This product is intended for research and analytical applications. (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.

Gliquidone sodium (AR-DF 26 sodium) can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone sodium significantly decreases LPS (HY-D1056)-induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone sodium can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone sodium also exhibits good anticancer activity in lung carcinoma cells. Gliquidone sodium has antioxidant property. Gliquidone sodium can be studied in research for type 2 diabetes and cancers.

N-Desmethyl clomipramine-d₇ (Desmethylclomipramine-d₇) is deuterium labeled N-Desmethyl clomipramine. Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research.

Thiamet G (Standard) is the analytical standard of Thiamet G (HY-12588). This product is intended for research and analytical applications. Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with K_i of 20 nM for human OGA.

H-89 (Standard) is the analytical standard of H-89 (HY-15979). This product is intended for research and analytical applications. H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein K_inase (protein K_inase A) with IC₅₀ of 48 nM and has weak inhibition on PKG, PKC, Casein K_inase, and others K_inases.

BNN-20 is a synthetic microneurotrophin that mimics brain-derived neurotrophic factor (BDNF) and exhibits area-specific pleiotropic neuroprotective and pro-neurogenic effects. BNN-20 can be utilized in research related to Parkinson's disease.

Phenglutarimid hydrochloride is an anticholinergic used as an antiparkinsonian agent.

Mephentermine is a sympathomimetic amine, frequently used as a vasopressor.

Pentoxyverine (Standard) is the analytical standard of Pentoxyverine. This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with K_is of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance.

GYKI 52466 (dihydrochloride) (Standard) is the analytical standard of GYKI 52466 (dihydrochloride). This product is intended for research and analytical applications. GYKI 52466 dihydrochloride is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC50 values of 7.5 and 11μM, respectively. GYKI 52466 dihydrochloride has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 dihydrochloride can be used in Parkinson's disease research.

4-CAB hydrochloride is an analog of p-chloroamphetamine, a psychoactive compound which inhibits the reuptake of serotonin (IC₅₀ = 330 nM) and dopamine (IC₅₀ = 2.3 μM).

AB-INACA is a metabolite of AB-CHMINACA.

Bromoriluzole is a derivative of Riluzole (HY-B0211). Bromoriluzole inhibits Ca²⁺ -dependent Calmodulin-SK4 channel interaction. Bromoriluzole is used for the research of neurodegenerative diseases.

Cotinine-d₃ N-β-D-Glucuronide is the deuterium labeled Cotinine N-β-D-Glucuronide (HY-W588194). Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function.

3,4-Difluoro propyl U-47700 is a utopioid.