Neurological Disease

2,2-Diphenyltetrahydrofuran (DPTHF) acts as a TRPV3 channel antagonist and is a structural analog of 2-Aminoethyl diphenylborinate (HY-W009724). 2,2-Diphenyltetrahydrofuran shows weak inhibitory activity against TRPV1 and TRPV2. It reduces hedonic feeding in mice exposed to Olanzapine (HY-14541). 2,2-Diphenyltetrahydrofuran can be used in the research of nervous system-related diseases.

Pramocaine (Pramoxine) is a topical surface anesthetic and antipruritic agent. Pramocaine reversibly inhibits voltage-gated sodium channel, reduces transmembrane permeability of sodium ions, stabilizes cell membranes, prevents depolarization, blocks action potential conduction, and inhibits peripheral slow C-fiber pathways associated with pain, pruritus and thermoception. Pramocaine can be used in research related to chronic pruritus, renal pruritus, atopic dermatitis, xerotic pruritus, uremic pruritus, and cutaneous hyperalgesia/pain.

Britannilactone diacetate (1,6-O,O-Diacetylbritannilactone; Compound 2) exhibits potential NO inhibition effect. Britannilactone diacetate exhibits activity against NO production induced by LPS in BV-2 microglial cells with the EC₅₀ value of 6.3 μM. Britannilactone diacetate exhibits a favorable blood-brain barriers (BBB) penetration and absorption, distribution, metabolism, excretion, and toxicity (ADMET) property.

Kuwanon G (Standard) is the analytical standard of Kuwanon G (HY-N4247). This product is intended for research and analytical applications. Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis.

Preclamol hydrochloride (Standard) is the analytical standard of Preclamol (hydrochloride) (HY-108698). This product is intended for research and analytical applications. Preclamol hydrochloride ((-)-3-PPP hydrochloride) is a selective dopamine autoreceptor agonist. Preclamol hydrochloride has the potential for the research of schizophrenia.

(R)-Amino-N-benzyl-3-methoxypropionamide (Standard) is the analytical standard of (R)-Amino-N-benzyl-3-methoxypropionamide. This product is intended for research and analytical applications. (R)-Amino-N-benzyl-3-methoxypropionamide is a stable intermediate of Lacosamide (an antiepileptic drug).

Naloxegol-¹³C,d₃ (NKTR-118-¹³C,d₃) is ¹³C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation.

p-Ethoxychrysoidin is a benzotriazole-based NLRP3 inhibitor. p-Ethoxychrysoidin can be used in research on inflammatory diseases and neurodegenerative diseases.

NNC 55-0396 free base is a blood-brain-barrier-permeable T-type Ca²⁺ channel inhibitor and pan-P450 inhibitor. NNC 55-0396 free base selectively inhibits T-type Ca²⁺ channels, suppresses HIF-1α expression and stability and inhibits Kv currents. NNC 55-0396 free base reduces brain infarct and attenuates neurological dysfunction. NNC 55-0396 free base inhibits the activity of multiple P450 enzymes. NNC 55-0396 (free base) can be used for the research of brain injury, hypertension, and glioblastoma.

DWP-05195 is a TRPV1 antagonist that can inhibit the pain signal transduction. DWP-05195 induces ER stress-dependent apoptosis through the ROS-p38-CHOP pathway in human ovarian cancer cells.

DL-Tyrosine (Standard) is the analytical standard of DL-Tyrosine (HY-Y0123). This product is intended for research and analytical applications. DL-Tyrosine is an aromatic nonessential amino acid synthesized from the essential amino acid phenylalanine. DL-Tyrosine is a precursor for several important neurotransmitters (epinephrine, norepinephrine, dopamine).

Bisindolylmaleimide VII is a potent inhibitor of calmodulin with high affinity for calmodulin (K_d=186.2 nM). Bisindolylmaleimide VII is used to study the role of calmodulin in cancer, neurodegenerative diseases, and muscle dysfunction.

5-Methoxy-N-isopropyl tryptamine is a tryptamine. 5-Methoxy-N-isopropyl tryptamine is a metabolite of 5-methoxy DiPT.

Nervon is a crystalline cerebroside. Nervon can be used for the research of peripheral neuropathies and megaloblastic anemia caused by vitamin B12 deficiency.

(R)-Baclofen hydrochloride (Arbaclofen hydrochloride) is a selective GABAB receptor agonist.

AZD-2066 hydrochloride is a selective, orally active and blood-brain barrier-permeating mGluR5 antagonist. AZD 2066 hydrochloride activates the BDNF/trkB signaling pathway. AZD 2066 hydrochloride can be used in the research of neuropathic pain, major depressive disorder and gastroesophageal reflux disease.

mPGES1-IN-3 is a selective, orally active mPGES-1 inhibitor with an IC₅₀ of 8.0 nM for h-mPGES-1 and an IC₅₀ of 10.79 nM for guinea pig mPGES1. mPGES1-IN-3 blocks the conversion of PGH2 (HY-136500) to PGE2 (HY-101952). mPGES1-IN-3 exhibits dose-dependent inhibition of LPS-induced thermal hyperalgesia. mPGES1-IN-3 can be used for research on rheumatoid arthritis.

Balipodect (Standard) is the analytical standard of Balipodect. This product is intended for research and analytical applications. Balipodect (TAK-063) is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.

Procurcumenol, a natural compound that can be isolated from Curcuma zedoaria Rhizomes, possesses neuroprotective and antioxidant activity. Procurcumenol can target CCR5 and has a significant inhibitory effect on platelet aggregation in vitro.

N-Ethyl-3,4-DMA (N-Ethyl-3,4-dimethoxyamphetamine) hydrochloride is an amphetamine.