2,2-Diphenyltetrahydrofuran
2,2-Diphenyltetrahydrofuran (DPTHF) acts as a TRPV3 channel antagonist and is a structural analog of 2-Aminoethyl diphenylborinate (HY-W009724). 2,2-Diphenyltetrahydrofuran shows weak inhibitory activity against TRPV1 and TRPV2. It reduces hedonic feeding in mice exposed to Olanzapine (HY-14541). 2,2-Diphenyltetrahydrofuran can be used in the research of nervous system-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 887-15-0
- Formula: C16H16O
- Molecular Weight:224.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
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TRPV3 |
TRPV1 |
TRPV2 |
TNF-α |
IL-6 |
In Vitro
2,2-Diphenyltetrahydrofuran (DPTHF) exerts multiple regulatory effects in HEK293 cells overexpressing TRPV3: it reversibly blocks TRPV3 calcium influx and whole-cell currents at ± 80 mV induced by 2-Aminoethyl diphenylborinate (HY-W009724) and DPBA; meanwhile, it directly and reversibly blocks heat-induced TRPV3 I2-phase currents; it also inhibits store-operated calcium entry in mammalian cells[2].
2,2-Diphenyltetrahydrofuran (100-500 μM) only weakly inhibits TRPV1 and TRPV2[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 18-23 g, metabolic alteration induced by 6 mg/kg olanzapine administered p.o. daily for 6 weeks)[1]
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Dosage:10 mg/kg; 20 mg/kg
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Administration:i.p.; daily; 6 weeks
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Result:Reduced weekly feed intake of olanzapine-treated mice (20 mg/kg, week 3-6), with unaltered intake at 10 mg/kg.
Lowered serum TNF-α and elevated hypothalamic POMC mRNA at 20 mg/kg and 10 mg/kg separately.
Downregulated TRPV3 mRNA in NAc, hypothalamus and VTA at both 10 mg/kg and 20 mg/kg, without altering TRPV1 mRNA in these regions.
Exerted no meaningful changes on body weight gain, weight change ratio, locomotor activity, body temperature, vWAT weight, adiposity index, serum glucose, insulin, HOMA-IR, OGTT-AUC, serum adiponectin, ghrelin, leptin, lipid profiles and serum IL-6 / NF-κB at two doses.
Chemical Information
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CAS No. 887-15-0
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Molecular Weight 224.30
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Formula C16H16O
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SMILES
O1CCCC1(C=2C=CC=CC2)C=3C=CC=CC3
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Synonyms
DPTHF
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2,2-Diphenyltetrahydrofuran Related Classifications
HY-184973 Related Classifications
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