country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-184973

Copy Link Print Information

2,2-Diphenyltetrahydrofuran

(Synonyms: DPTHF)

2,2-Diphenyltetrahydrofuran (DPTHF) acts as a TRPV3 channel antagonist and is a structural analog of 2-Aminoethyl diphenylborinate (HY-W009724). 2,2-Diphenyltetrahydrofuran shows weak inhibitory activity against TRPV1 and TRPV2. It reduces hedonic feeding in mice exposed to Olanzapine (HY-14541). 2,2-Diphenyltetrahydrofuran can be used in the research of nervous system-related diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 887-15-0
Formel: C₁₆H₁₆O
Molecular Weight:224.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

2,2-Diphenyltetrahydrofuran Chemical Structure

CAS. Nr.: 887-15-0

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[2]^[1]

TRPV3

TRPV1

TRPV2

TNF-α

IL-6

Alle TRP Channel Isoform-spezifische Produkte anzeigen :

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

2,2-Diphenyltetrahydrofuran (DPTHF) exerts multiple regulatory effects in HEK293 cells overexpressing TRPV3: it reversibly blocks TRPV3 calcium influx and whole-cell currents at ± 80 mV induced by 2-Aminoethyl diphenylborinate (HY-W009724) and DPBA; meanwhile, it directly and reversibly blocks heat-induced TRPV3 I₂-phase currents; it also inhibits store-operated calcium entry in mammalian cells^[2].
2,2-Diphenyltetrahydrofuran (100-500 μM) only weakly inhibits TRPV1 and TRPV2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

2,2-Diphenyltetrahydrofuran (DPTHF) (10-20 mg/kg; i.p.; daily; 6 weeks) reduces food intake and serum TNF-α levels, and decreases TRPV3 mRNA expression in key brain regions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female, 18-23 g, metabolic alteration induced by 6 mg/kg olanzapine administered p.o. daily for 6 weeks)^[1]
Dosage:

10 mg/kg; 20 mg/kg
Administration:

i.p.; daily; 6 weeks
Result:

Reduced weekly feed intake of olanzapine-treated mice (20 mg/kg, week 3-6), with unaltered intake at 10 mg/kg.
Lowered serum TNF-α and elevated hypothalamic POMC mRNA at 20 mg/kg and 10 mg/kg separately.
Downregulated TRPV3 mRNA in NAc, hypothalamus and VTA at both 10 mg/kg and 20 mg/kg, without altering TRPV1 mRNA in these regions.
Exerted no meaningful changes on body weight gain, weight change ratio, locomotor activity, body temperature, vWAT weight, adiposity index, serum glucose, insulin, HOMA-IR, OGTT-AUC, serum adiponectin, ghrelin, leptin, lipid profiles and serum IL-6 / NF-κB at two doses.

Chemical Information

CAS. Nr. 887-15-0
Molecular Weight 224.30
Formel C₁₆H₁₆O
SMILES

O1CCCC1(C=2C=CC=CC2)C=3C=CC=CC3
Synonyms

DPTHF
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Singh R, et al. Role of TRPV1/TRPV3 channels in olanzapine-induced metabolic alteration: Possible involvement in hypothalamic energy-sensing, appetite regulation, inflammation and mesolimbic pathway. Toxicology and applied pharmacology. 2020 Sep 01;402:115124. [Content Brief]

[2]. Chung M‑K, et al. Biphasic Currents Evoked by Chemical or Thermal Activation of the Heat‑gated Ion Channel, TRPV3. Journal of Biological Chemistry, 2005, 280(16): 15928‑15941.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

2,2-Diphenyltetrahydrofuran

Alle TRP Channel Isoform-spezifische Produkte anzeigen

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Alle Interleukin Related Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

2,2-Diphenyltetrahydrofuran Related Classifications

HY-184973 Related Classifications