2,2-Diphenyltetrahydrofuran
2,2-Diphenyltetrahydrofuran (DPTHF) acts as a TRPV3 channel antagonist and is a structural analog of 2-Aminoethyl diphenylborinate (HY-W009724). 2,2-Diphenyltetrahydrofuran shows weak inhibitory activity against TRPV1 and TRPV2. It reduces hedonic feeding in mice exposed to Olanzapine (HY-14541). 2,2-Diphenyltetrahydrofuran can be used in the research of nervous system-related diseases.
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- No. CAS: 887-15-0
- Fòrmula: C16H16O
- Peso molecular:224.30
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Almacenamiento:
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Actividad biológica
Descripciòn
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TRPV3 |
TRPV1 |
TRPV2 |
TNF-α |
IL-6 |
In Vitro
2,2-Diphenyltetrahydrofuran (DPTHF) exerts multiple regulatory effects in HEK293 cells overexpressing TRPV3: it reversibly blocks TRPV3 calcium influx and whole-cell currents at ± 80 mV induced by 2-Aminoethyl diphenylborinate (HY-W009724) and DPBA; meanwhile, it directly and reversibly blocks heat-induced TRPV3 I2-phase currents; it also inhibits store-operated calcium entry in mammalian cells[2].
2,2-Diphenyltetrahydrofuran (100-500 μM) only weakly inhibits TRPV1 and TRPV2[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 18-23 g, metabolic alteration induced by 6 mg/kg olanzapine administered p.o. daily for 6 weeks)[1]
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Dosage:10 mg/kg; 20 mg/kg
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Administration:i.p.; daily; 6 weeks
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Result:Reduced weekly feed intake of olanzapine-treated mice (20 mg/kg, week 3-6), with unaltered intake at 10 mg/kg.
Lowered serum TNF-α and elevated hypothalamic POMC mRNA at 20 mg/kg and 10 mg/kg separately.
Downregulated TRPV3 mRNA in NAc, hypothalamus and VTA at both 10 mg/kg and 20 mg/kg, without altering TRPV1 mRNA in these regions.
Exerted no meaningful changes on body weight gain, weight change ratio, locomotor activity, body temperature, vWAT weight, adiposity index, serum glucose, insulin, HOMA-IR, OGTT-AUC, serum adiponectin, ghrelin, leptin, lipid profiles and serum IL-6 / NF-κB at two doses.
Chemical Information
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No. CAS 887-15-0
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Peso molecular 224.30
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Fòrmula C16H16O
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SMILES
O1CCCC1(C=2C=CC=CC2)C=3C=CC=CC3
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Synonyms
DPTHF
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2,2-Diphenyltetrahydrofuran Related Classifications
HY-184973 Related Classifications
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